Weight change 2 years after termination of the intensive lifestyle intervention in the Look AHEAD study.
Open accessAbstract
Objective: This study evaluated weight changes after cessation of the 10‐year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2‐year observational period following termination of weight‐loss–maintenance counseling than would participants in the diabetes support and education (DSE) control group. Methods: Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012. Results: Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean (SE) of 1.2 (0.2) kg and 1.8 (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained ≥ 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost ≥ 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight‐control behaviors than DSE participants. Conclusions: Both groups lost weight during the 2‐year follow‐up period, but more ILI than DSE participants gained ≥ 2% of EOI weight. Further understanding is needed of factors that affected long‐term weight change in both groups.
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Weight regain occurs in 25% or more of participants at 2-year follow-up after multicomponent behavioral interventions.
“although weight regain occurs in 25% or more of participants at 2-year follow-up.”
From Obesity Management in Adults (2023) · cites this paper as [46]
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References 37 · Cited by 40
- Authors
- Look AHEAD Research Group, Chao, A. M., Wadden, T. A., Berkowitz, R. I., Blackburn, G., Bolin, P., Clark, J. M., Coday, M., Curtis, J. M., Delahanty, L. M., Dutton, G. R., Evans, M., Ewing, L. J., Foreyt, J. P., Gay, L. J., Gregg, E. W., Hazuda, H. P., Hill, J. O., Horton, E. S., Houston, D. K., Jakicic, J. M., Jeffery, R. W., Johnson, K. C., Kahn, S. E., Knowler, W. C., Kure, A., Michalski, K. L., Montez, M. G., Neiberg, R. H., Patricio, J., Peters, A., Pi‐Sunyer, X., Pownall, H., Reboussin, D., Redmon, B., Rejeski, W. J., Steinburg, H., Walker, M., Williamson, D. A., Wing, R. R., Wyatt, H., Yanovski, S. Z., & Zhang, P.
- Affiliations
- University of Pennsylvania (US)
- Beth Israel Deaconess Medical Center (US)
- St. Joseph's Hospital and Medical Center (US)
- Johns Hopkins University (US)
- University of Tennessee Health Science Center (US)
- Massachusetts General Hospital (US)
- University of Alabama at Birmingham (US)
- National Institutes of Health (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- Brown University (US)
- Centers for Disease Control and Prevention (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Colorado Anschutz (US)
- Joslin Diabetes Center (US)
- Wake Forest University Health Sciences (US)
- University of Minnesota (US)
- University of Washington (US)
- St. Luke's-Roosevelt Hospital Center (US)
- University of Southern California (US)
- Divisions of Epidemiology and Community Health University of Minnesota Minneapolis Minnesota USA
- Pennington Biomedical Research Center (US)
- Corresponding author
- Chao, Ariana M.
- ORCID
- Chao, Ariana M.
- Wadden, Thomas A.
- Berkowitz, Robert I.
- Clark, Jeanne M.
- Coday, Mace
- Delahanty, Linda M.
- Dutton, Gareth R.
- Evans, Mary
- Ewing, Linda J.
- Gregg, Edward W.
- Hazuda, Helen P.
- Hill, James O.
- Horton, Edward S.
- Houston, Denise K.
- Jakicic, John M.
- Johnson, Karen C.
- Kahn, Steven E.
- Knowler, William C.
- Neiberg, Rebecca H.
- Peters, Anne
- Pownall, Henry
- Reboussin, David
- Rejeski, W. Jack
- Wing, Rena R.
- Wyatt, Holly
- Yanovski, Susan Z.
- Zhang, Ping
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2020-04-22
- Volume
- 28
- Issue
- 5
- Pages
- 893-901
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC7437140
- OpenAlex
- W3016710586
- Cited by
- 40
- References
- 37
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 4 · 2017: 1
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- National Institute on Minority Health and Health Disparities
- Centers for Disease Control and Prevention
- Office of Research on Women's Health
- Indian Health Service
- National Institute of Diabetes and Digestive and Kidney Diseases (DK56990, DK56992, DK57002, DK57008, DK57078, DK57131, DK57135, DK57136, DK57149, DK57151, DK57154, DK57171, DK57177, DK57178, DK57182, DK57219)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- weight change, intensive lifestyle intervention, Look AHEAD trial, type 2 diabetes, weight loss maintenance, weight regain, diabetes support and education, weight control behaviors, overweight
- MeSH terms
- Aged, Female, Humans, Life Style, Male, Middle Aged, Obesity, Weight Loss
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