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Cited by 113Regulation of Appetite and ObesityPharmacology and Obesity TreatmentObesity, Physical Activity, Diet

Describing the Weight‐Reduced State: Physiology, Behavior, and Interventions

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Aronne, Louis J., Hall, Kevin D., M. Jakicic, John, Leibel, Rudolph L., Lowe, Michael R., Rosenbaum, Michael, Klein, Samuel·2021·Obesity
DOI 10.1002/oby.23086PMC PMC9022199
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Abstract

Although many persons with obesity can lose weight by lifestyle (diet and physical activity) therapy, successful long‐term weight loss is difficult to achieve, and most people who lose weight regain their lost weight over time. The neurohormonal, physiological, and behavioral factors that promote weight recidivism are unclear and complex. The National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop in June 2019, titled “The Physiology of the Weight‐Reduced State,” to explore the mechanisms and integrative physiology of adaptations in appetite, energy expenditure, and thermogenesis that occur in the weight‐reduced state and that may oppose weight‐loss maintenance. The proceedings from the first session of this workshop are presented here. Drs. Michael Rosenbaum, Kevin Hall, and Rudolph Leibel discussed the physiological factors that contribute to weight regain; Dr. Michael Lowe discussed the biobehavioral issues involved in weight‐loss maintenance; Dr. John Jakicic discussed the influence of physical activity on long‐term weight‐loss maintenance; and Dr. Louis Aronne discussed the ability of drug therapy to maintain weight loss.

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Authors
Aronne, L. J., Hall, K. D., M. Jakicic, J., Leibel, R. L., Lowe, M. R., Rosenbaum, M., & Klein, S.
Affiliations
  • Weill Cornell Medicine (US)
  • National Institutes of Health (US)
  • Healthy Lifestyle Institute University of Pittsburgh Pittsburgh Pennsylvania USA
  • Columbia University Irving Medical Center (US)
  • Drexel University (US)
  • Washington University in St. Louis (US)
Corresponding author
  • Lowe, Michael R.
  • Rosenbaum, Michael
  • Klein, Samuel
ORCID
Venue
Obesity
Publisher
Wiley
Published
2021-03-23
Volume
29
Issue
S1
Pages
S9-S24
ISSN
  • 1930-7381 (ISSN-L)
  • 1930-739X
DOI
10.1002/oby.23086
PMC
PMC9022199
OpenAlex
W3138276176
Cited by
113
References
158
Citations by year
2026: 19 · 2025: 26 · 2024: 19 · 2023: 26 · 2022: 15 · 2021: 8
FWCI
8.92
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (DK 52431, NIH UL1 TR00040)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
weight regain, weight loss maintenance, appetite regulation, energy expenditure, thermogenesis, lifestyle therapy, physical activity, biobehavioral factors
MeSH terms
Body Weight Maintenance, Adaptation, Physiological, Appetite, Diet, Energy Metabolism, Humans, Life Style, Obesity, United States, Weight Loss, Health Behavior, Exercise, Thermogenesis, National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)

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