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Response of mouse lung to crocidolite asbestos. 1. Minimal fibrotic reaction to short fibres
Abstract
To determine the relationship between the development of pulmonary fibrosis and the size of deposited asbestos, we prepared a pure sample of short crocidolite fibres and instilled 0.5 mg of 0.1 mg to the lungs of mice. Animals were killed up to 20 weeks later with 3 H thymidine injected 1 h before death. By bronchoalveolar lavage, there was a rapid transient increase in polymorph neutrophils (PMN) and in glucosaminidase levels; alveolar macrophage (AM) numbers were elevated in the 0.5 mg group for eight weeks. Most fibres were phagocytized by AM, many of which were heavily laden and cleared from the lung over the 20 week period. Some fibres were seen in type 1 epithelial cells, frequently associated with cell injury. From cell kinetic studies, a very brief proliferative response was seen in bronchiolar epithelial and Type 2 alveolar epithelial cells. A greater response was seen in interstitial fibroblasts which showed increased labelling up to two weeks after 0.5 mg asbestos. However no granulomas were seen and very little fibrosis was found by morphology or by biochemistry at any time after 0.5 mg; no fibrosis was seen after instilling 0.1 mg. The results show that a high dose of exclusively short asbestos fibres produces minimal lung injury and fibrosis in spite of long standing macrophage‐fibre interaction in the alveoli.
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In the citing paper
“After instillation of the same dose of long fibers, early lesions in the bronchial and bronchiolar epithelium were identified at the site of fiber deposition, with development of granulomas.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“Similar results were obtained by the observation of pleural mesothelial and subpleural cells.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“A small and transient increase in the percentage of lung cells incorporating 3HdThd was observed in mice treated with the sample of short fibers compared to control mice.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“In earlier work, the authors noted that alveolar macrophages secrete a growth factor for fibroblasts in response to SAF, likely accounting for these effects.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“The cellular damage was minimal and reversible.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“Almost all short fibers were phagocytosed by alveolar macrophages, and only a few fibers reached the interstitium, but no cellular injury was highlighted here.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“The samples studied were UICC crocidolite (average length 24.4 ± 0.5 μm; 12% < 2.5 μm) and a fraction of short fibers in the UICC sample separated by sedimentation (average length 0.6 ± 0.1 μm; 99% < 2.5 μm).”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“Exposure to the sample of short fibers resulted in phagocytosis and in a brief inflammatory response (<15 days).”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“A greater increase was found after exposure to the sample of long fibers, also transient but of a longer duration.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
In the citing paper
“The authors also noted that the sample of long fibers caused the formation of small foci of lymphoid tissue at the pleural surface, attached to the underlying subpleural connective tissue.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [68]
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Research works printed but not linked: 18
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MOSSMAN, B. T., & CHURG, A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.5.9707141 · Cited by 971
Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Tomatis, M., Turci, F., Ceschino, R., Riganti, C., Gazzano, E., Martra, G., Ghigo, D., & Fubini, B. (2010) · Inhalation Toxicology · doi:10.3109/08958378.2010.504243 · Cited by 53
Metadata
- Authors
- Adamson, I. Y. R., & Bowden, D. H.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 1987-06
- Volume
- 152
- Issue
- 2
- Pages
- 99-107
- ISSN
- 0022-3417
- 1096-9896
- Cited by
- 45
- References
- 0
- Language
- en
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