The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables
Abstract
Sixty cases of primary breast carcinoma have been studied using a monoclonal antibody, Ki67, which recognizes an antigen expressed by cells in G1, S, G2, and M phases of the cell cycle but not Go. A Ki67 score (positive cells/total tumour cells) was determined, and possible relationships between this index of cellular proliferation and a number of clinical and pathological parameters were investigated. There was a strong positive correlation between the Ki67 score and mitotic index ( p < 0.001), a weak negative correlation with age ( p < 0.02), and weak positive correlations with histological tumour grade ( p < 0.03), tumour necrosis ( p < 0.01), and cellular reaction ( p < 0.01). No relationship was noted between the Ki67 score and tumour size, nodal status, tumour oestrogen receptor levels, or menopausal status. The Ki67 score may prove to be an objective indicator of biological behaviour and thus be of clinical significance, particularly since it is not strongly related to other clinical and pathological parameters used in predicting outcome in breast carcinoma.
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Citations
Cites
Gerdes, J., Lemke, H., Baisch, H., Wacker, H. H., Schwab, U., & Stein, H. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.4.1710 · Cited by 4,173
Cited by
The prognostic value of Ki67 immunostaining in non‐Hodgkin's lymphoma
Hall, P. A., Richards, M. A., Gregory, W. M., D'Ardenne, A. J., Lister, T. A., & Stansfeld, A. G. (1988) · The Journal of Pathology · doi:10.1002/path.1711540305 · Cited by 304
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Metadata
- Authors
- Barnard, N. J., Hall, P. A., Lemoine, N. R., & Kadar, N.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 1987-08
- Volume
- 152
- Issue
- 4
- Pages
- 287-295
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2015825004
- Cited by
- 243
- References
- 1
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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