The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The function of immunoglobulin A in immunity
Abstract
The vast surfaces of the gastrointestinal, respiratory, and genitourinary tracts represent major sites of potential attack by invading micro‐organisms. Immunoglobulin A (IgA), as the principal antibody class in the secretions that bathe these mucosal surfaces, acts as an important first line of defence. IgA, also an important serum immunoglobulin, mediates a variety of protective functions through interaction with specific receptors and immune mediators. The importance of such protection is underlined by the fact that certain pathogens have evolved mechanisms to compromise IgA‐mediated defence, providing an opportunity for more effective invasion. IgA function may also be perturbed in certain disease states, some of which are characterized by deposition of IgA in specific tissues. This review details current understanding of the roles played by IgA in both health and disease. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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LANG, M. L., CHEN, Y.-W., SHEN, L., GAO, H., LANG, G. A., WADE, T. K., & WADE, W. F. (2002) · Biochemical Journal · doi:10.1042/bj20011696 · Cited by 60
Cited by
Yel, L. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9357-x · Cited by 580
Kim, J., Eygeris, Y., Gupta, M., & Sahay, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.014 · Cited by 514
The Effects of Secretory IgA in the Mucosal Immune System
Li, Y., Jin, L., & Chen, T. (2020) · BioMed Research International · doi:10.1155/2020/2032057 · Cited by 336
The inflammatory function of human IgA
Hansen, I. S., Baeten, D. L. P., & den Dunnen, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2976-8 · Cited by 170
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
Hwang*, J. K., Alt*, F. W., & Yeap, L.-S. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0037-2014 · Cited by 126
Metadata
- Authors
- Woof, J. M., & Kerr, M. A.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2005-12-17
- Volume
- 208
- Issue
- 2
- Pages
- 270-282
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2164678711
- Cited by
- 716
- References
- 1
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
