Mechanisms of age‐related macular degeneration and therapeutic opportunities
Abstract
As the age of the population increases in many nations, age‐related degenerative diseases pose significant socioeconomic challenges. One of the key degenerative diseases that compromise quality of life is age‐related macular degeneration ( AMD ). AMD is a multi‐faceted condition that affects the central retina, which ultimately leads to blindness in millions of people worldwide. The pathophysiology and risk factors for AMD are complex, and the symptoms manifest in multiple related but distinct forms. The ability to develop effective treatments for AMD will depend on a thorough understanding of the underlying pathophysiology, risk factors, and driver molecular pathways, as well as the ability to develop useful animal models. This review provides an overview of the aforementioned aspects in AMD . Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Markers of autophagy and exosomes have been found in the RPE of aged mice as well as in drusen from cadaveric eyes from people with age-related macular degeneration (AMD).
“For example, markers of autophagy and exosomes have been found in the RPE of aged mice as well as in drusen from cadaveric eyes from people with age-related macular degeneration (AMD), 16”
From Deletion of autophagy inducer <i>RB1CC1</i> results in degeneration of the retinal pigment epithelium (2015) · cites this paper as [16]
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References 149 · Cited by 382
- Authors
- van Lookeren Campagne, M., LeCouter, J., Yaspan, B. L., & Ye, W.
- Affiliations
- Immunology Department Genentech South San Francisco CA 94080 USA
- Genentech (US)
- Corresponding author
- Ye, Weilan
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2013-12-10
- Volume
- 232
- Issue
- 2
- Pages
- 151-164
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2145027167
- Semantic Scholar
- bd1d6a063694e940a23bc6528c3142aeacacefdf
- Cited by
- 382
- References
- 149
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 45 · 2023: 41 · 2022: 31 · 2021: 43 · 2020: 38 · 2019: 23 · 2018: 32 · 2017: 28 · 2016: 26 · 2015: 23 · 2014: 13 · 2013: 1 · 2012: 1
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related macular degeneration, pathophysiology, risk factors, molecular pathways, animal models, AMD treatment, retinal degeneration, blindness
- MeSH terms
- Animals, Disease Models, Animal, Humans, Macular Degeneration, Phenotype, Retina, Genetic Predisposition to Disease, Drug Discovery, Molecular Targeted Therapy
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