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The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours

Open access
Galon, Jérôme, Mlecnik, Bernhard, Bindea, Gabriela, Angell, Helen K, Berger, Anne, Lagorce, Christine, Lugli, Alessandro, Zlobec, Inti, Hartmann, Arndt, Bifulco, Carlo, Nagtegaal, Iris D, Palmqvist, Richard, Masucci, Giuseppe V, Botti, Gerardo, Tatangelo, Fabiana, Delrio, Paolo, Maio, Michele, Laghi, Luigi, Grizzi, Fabio, Asslaber, Martin, D'Arrigo, Corrado, Vidal‐Vanaclocha, Fernando, Zavadova, Eva, Chouchane, Lotfi, Ohashi, Pamela S, Hafezi‐Bakhtiari, Sara, Wouters, Bradly G, Roehrl, Michael, Nguyen, Linh, Kawakami, Yutaka, Hazama, Shoichi, Okuno, Kiyotaka, Ogino, Shuji, Gibbs, Peter, Waring, Paul, Sato, Noriyuki, Torigoe, Toshihiko, Itoh, Kyogo, Patel, Prabhu S, Shukla, Shilin N, Wang, Yili, Kopetz, Scott, Sinicrope, Frank A, Scripcariu, Viorel, Ascierto, Paolo A, Marincola, Francesco M, Fox, Bernard A, Pagès, Franck·2014·The Journal of Pathology
DOI 10.1002/path.4287
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Abstract

The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression‐based stratification. These parameters rely on tumour‐cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named ‘Immunoscore’ has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM‐I (TNM‐Immune). © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

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Metadata

Authors
Galon, J., Mlecnik, B., Bindea, G., Angell, H. K., Berger, A., Lagorce, C., Lugli, A., Zlobec, I., Hartmann, A., Bifulco, C., Nagtegaal, I. D., Palmqvist, R., Masucci, G. V., Botti, G., Tatangelo, F., Delrio, P., Maio, M., Laghi, L., Grizzi, F., Asslaber, M., D'Arrigo, C., Vidal‐Vanaclocha, F., Zavadova, E., Chouchane, L., Ohashi, P. S., Hafezi‐Bakhtiari, S., Wouters, B. G., Roehrl, M., Nguyen, L., Kawakami, Y., Hazama, S., Okuno, K., Ogino, S., Gibbs, P., Waring, P., Sato, N., Torigoe, T., Itoh, K., Patel, P. S., Shukla, S. N., Wang, Y., Kopetz, S., Sinicrope, F. A., Scripcariu, V., Ascierto, P. A., Marincola, F. M., Fox, B. A., & Pagès, F.
Venue
The Journal of Pathology
Publisher
Wiley
Published
2013-12-10
Volume
232
Issue
2
Pages
199-209
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
DOI
10.1002/path.4287
OpenAlex
W1859257957
Cited by
1,360
References
12
FWCI
40.79
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours. https://app.cochat.ai/papers/10.1002/path.4287
The paper
Galon, J., Mlecnik, B., Bindea, G., Angell, H. K., Berger, A., Lagorce, C., Lugli, A., Zlobec, I., Hartmann, A., Bifulco, C., Nagtegaal, I. D., Palmqvist, R., Masucci, G. V., Botti, G., Tatangelo, F., Delrio, P., Maio, M., Laghi, L., Grizzi, F., . . . Pagès, F. (2014). Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours. The Journal of Pathology. https://doi.org/10.1002/path.4287

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.