The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities
Abstract
The alpha subunit of human chorionic gonadotropin (alpha‐hCG), human chorionic gonadotropin (hCG) and alpha fetoprotein (AFP) were measured in the serum of 25 women with chromosomally abnormal fetuses between 18 and 25 weeks of gestation and in 74 normal pregnancies. AFP levels less than 0.5 multiples of the median (MoM) or greater than 2.5 MoM were observed in 24 per cent of the abnormal pregnancies and in 6.76 per cent of the normal pregnancies. A low concentration of hCG (< 0.25 MoM) was observed in 8 per cent of abnormals and in 2.7 per cent of normals while an elevated concentration of hCG (>2.5 MoM) was observed in 56 per cent of abnormals and in 1.35 per cent of normals. Elevated hCG‐alpha (>2.5 MoM) was observed in 28 per cent of abnormals and in none of the normals. Determination of elevated levels of hCG‐alpha or hCG resulted in detection of 68 per cent of pregnancies with chromosomally abnormal fetuses with a false positive rate of 1.35 per cent. Determination of both elevated and depressed gonadotropin levels resulted in detection of 76 per cent of abnormal pregnancies with a false positive rate of 4.05 per cent. Measurement of hCG and hCG‐alpha in maternal serum samples can be used as a screening procedure for detecting pregnancies at risk for fetal chromosome abnormalities.
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Citations
Cites
An association between low maternal serum α-fetoprotein and fetal chromosomal abnormalities
Merkatz, I. R., Nitowsky, H. M., Macri, J. N., & Johnson, W. E. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90530-1 · Cited by 735
Early embryonic mortality in women
Edmonds, D. K., Lindsay, K. S., Miller, J. F., Williamson, E., & Wood, P. J. (1982) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46579-9 · Cited by 512
Ferguson‐Smith, M. A., & Yates, J. R. W. (1984) · Prenatal Diagnosis · doi:10.1002/pd.1970040704 · Cited by 387
Serum human chorionic gonadotropin levels throughout normal pregnancy
Braunstein, G. D., Rasor, J., Adler, D., Danzer, H., & Wade, M. E. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90518-4 · Cited by 259
Cited by
Toll, H., Berger, P., Hofmann, A., Hildebrandt, A., Oberacher, H., Lenhof, H. P., & Huber, C. G. (2006) · ELECTROPHORESIS · doi:10.1002/elps.200600022 · Cited by 42
Metadata
- Authors
- Bogart, M. H., Pandian, M. R., & Jones, O. W.
- Venue
- Prenatal Diagnosis
- Publisher
- Wiley
- Published
- 1987-11
- Volume
- 7
- Issue
- 9
- Pages
- 623-630
- ISSN
- 0197-3851 (ISSN-L)
- 1097-0223
- OpenAlex
- W2021764835
- Cited by
- 473
- References
- 4
- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bogart, M. H., Pandian, M. R., & Jones, O. W. (1987). Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities. Prenatal Diagnosis. https://doi.org/10.1002/pd.1970070904
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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