Posterior brain in fetuses with open spina bifida at 11 to 13 weeks
Abstract
Objective: To measure the changes in the posterior fossa in first‐trimester fetuses with open spina bifida (OSB). Methods: The brain stem diameter and brain stem to occipital bone (BSOB) diameter were measured in stored images of the mid‐sagittal view of the fetal face at 11+0 to 13+6 weeks from 30 fetuses with OSB and 1000 normal controls. Results: In the control group, the brain stem and BSOB diameter increased significantly with crown‐rump length (CRL) and the brain stem to BSOB ratio decreased. In the spina bifida group, the brain stem diameter was above the 95th percentile of the control group in 29 (96.7%) cases, the BSOB diameter was below the 5th percentile in 26 (86.7%) and the brain stem to BSOB ratio was above the 95th percentile in all cases. Conclusions: At 11 to 13 weeks the majority of fetuses with OSB have measurable abnormalities in the posterior brain. Copyright © 2010 John Wiley & Sons, Ltd.
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Abnormalities in the cranial posterior fossa serve as a valuable ultrasound marker of spinal abnormalities.
“and therefore serves as a valuable ultrasound marker of spinal abnormalities [75].”
From First-Trimester Ultrasound: A Comparative Review of Guidelines (2026) · cites this paper as [75]
Abnormalities in the cranial posterior fossa are associated with open spina bifida in the majority of cases.
“as published data have shown that abnormalities in this anatomic area are associated with open spina bifida in the majority of cases”
From First-Trimester Ultrasound: A Comparative Review of Guidelines (2026) · cites this paper as [75]
Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965 · see citing works
Snijders, R., Noble, P., Sebire, N., Souka, A., & Nicolaides, K. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11280-6 · Cited by 1,572 · cited 1× · see citing works
“The cases and controls were obtained from centres providing routine first-trimester screening for chromosomal abnormalities by measurement of fetal NT thickness (Snijders et al., 1998).”
MethodEvaluation of the lemon and banana signs in one hundred thirty fetuses with open spina bifida
Van den Hof, M. C., Nicolaides, K. H., Campbell, J., & Campbell, S. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90378-k · Cited by 207 · see citing works
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First-Trimester Ultrasound: A Comparative Review of Guidelines
Boureka, E., Tsakiridis, I., Michos, G., Liberis, A., Giouleka, S., Mamopoulos, A., Kalogiannidis, I., & Dagklis, T. (2026) · Diagnostics · doi:10.3390/diagnostics16111695
- Authors
- Lachmann, R., Chaoui, R., Moratalla, J., Picciarelli, G., & Nicolaides, K. H.
- Affiliations
- University College Hospital (GB)
- Harris Birthright Research Centre for Fetal Medicine (GB)
- Corresponding author
- Nicolaides, Kypros H.
- Venue
- Prenatal Diagnosis
- Publisher
- Wiley
- Published
- 2010-12-28
- Volume
- 31
- Issue
- 1
- Pages
- 103-106
- ISSN
- 0197-3851 (ISSN-L)
- 1097-0223
- OpenAlex
- W2077830707
- Cited by
- 176
- References
- 3
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 9 · 2023: 7 · 2022: 4 · 2021: 10 · 2020: 16 · 2019: 15 · 2018: 5 · 2017: 12 · 2016: 13 · 2015: 18 · 2014: 12 · 2013: 12 · 2012: 20
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prenatal Diagnosis (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Fetal Medicine Foundation (1037116)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Spinal Dysraphism and Malformations
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Keywords
- open spina bifida, posterior fossa, fetal brain anomalies, crown-rump length
- MeSH terms
- Brain, Brain Stem, Echoencephalography, Female, Gestational Age, Humans, Occipital Bone, Pregnancy, Observer Variation, Spina Bifida Cystica, Ultrasonography, Prenatal, Crown-Rump Length, Nuchal Translucency Measurement
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