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Characteristics and external validity of the German Health Risk Institute (HRI) Database
Abstract
PURPOSE: The aim of this study was to describe characteristics and external validity of the German Health Risk Institute (HRI) Database. METHODS: The HRI Database is an anonymized healthcare database with longitudinal data from approximately six Mio Germans. In addition to demographic information (gender, age, region of residence), data on persistence of insurants over time, hospitalization rates, mortality rates and drug prescription rates were extracted from the HRI database for 2013. Corresponding national reference data were obtained from official sources. RESULTS: The proportion of men and women was similar in the HRI Database and Germany, but the database population was slightly younger (mean 40.4 vs 43.7 years). The proportion of insurants living in the eastern part of Germany was lower in the HRI Database (10.1% vs 19.7%). There was good accordance to German reference data with respect to hospitalization rates, overall mortality rate and prescription rates for the 20 most often reimbursed drug classes, with the overall burden of morbidity being slightly lower in the HRI database. From insurants insured on 1 January 2009 (N = 6.2 Mio), a total of 70.6% survived and remained continuously insured with the same statutory health insurance until 31 December 2013. This proportion increased to 77.5% if only insurants ≥40 years were considered. CONCLUSIONS: There was good overall accordance of the HRI database and the German population in terms of measures of morbidity, mortality and drug usage. Persistence of insurants with the database over time was high, indicating suitability of the data source for longitudinal epidemiological analyses.
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“The WIG2 research database provides data representative of the German population with respect to age and gender distribution and includes anonymized data on the healthcare use and resource consumption of 4.5 million member records from nationwide statutory health insurances (SHIs) [33,34].”
From Diagnostic Yield and Clinical Implications of Implantable Loop Recorders in Patients with Syncope in Germany: A National Database Analysis (2024) · cites this paper as [33]
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References 7 · Cited by 197
Research works printed but not linked: 8
- Hoffmann, 2009, Review on use of German health insurance medication claims data for epidemiological research, Pharmacoepidemiol Drug Saf, 18, 349, 10.1002/pds.1721 · DOI
- Pigeot, 2008, Establishment of a pharmacoepidemiological database in Germany: methodological potential, scientific value and practical limitations, Pharmacoepidemiol Drug Saf, 17, 215, 10.1002/pds.1545 · DOI
- Ihle, 2005, Sample survey of persons insured in statutory health insurance institutions in Hessen-concept and realisation of person-related data base] [Article in German, Gesundheitswesen, 67, 638, 10.1055/s-2005-858598 · DOI
- 2014, Arzneiverordnungs-Report 2014
- Andersohn, 2010, Regional variation of mortality from ischemic heart disease in Germany from 1998 to 2007, Clin Res Cardiol, 99, 511, 10.1007/s00392-010-0150-x · DOI
- Müller-Nordhorn, 2004, Regional variation and time trends in mortality from ischaemic heart disease: East and West Germany 10 years after reunification, J Epidemiol Community Health, 58, 481, 10.1136/jech.2003.013367 · DOI
- Ohlmeier, 2015, Mortality in the German Pharmacoepidemiological Research Database (GePaRD) compared to national data in Germany: results from a validation study, BMC Public Health, 15, 570, 10.1186/s12889-015-1943-7 · DOI
- Hoffmann, 2012, Structural differences between health insurance funds and their impact on health services research: results from the Bertelsmann Health-Care Monitor]. [Article in German, Gesundheitswesen, 74, 291, 10.1055/s-0031-1275711 · DOI
Metadata
- Authors
- Andersohn, F., & Walker, J.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Elsevier GmbH; Munich Germany
- Corresponding author
- Andersohn, Frank
- Venue
- Pharmacoepidemiology and Drug Safety
- Publisher
- Wiley
- Published
- 2015-11-03
- Volume
- 25
- Issue
- 1
- Pages
- 106-109
- ISSN
- 1053-8569 (ISSN-L)
- OpenAlex
- W2166154381
- Cited by
- 197
- References
- 7
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 21 · 2022: 43 · 2021: 33 · 2020: 36 · 2019: 18 · 2018: 11 · 2017: 11 · 2016: 6
- FWCI
- 17.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Pharmacoepidemiology and Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Studies
- Health Sciences › Health Professions › Health Information Management › Medical Coding and Health Information
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Healthcare Policy and Management
- Keywords
- generalizability, population representativeness, hospitalization rates, mortality rates, German statutory health insurance
- MeSH terms
- Adult, Female, Germany, Health Status Indicators, Hospitalization, Humans, Insurance, Health, Male, National Health Programs, Drug Prescriptions, Rural Population, Urban Population, Databases, Factual
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- Andersohn, F., & Walker, J. (2016). Characteristics and external validity of the German Health Risk Institute (HRI) Database. Pharmacoepidemiology and Drug Safety. https://doi.org/10.1002/pds.3895