Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling

Kittikulsuth, Wararat; Stuart, Deborah; Kohan, Donald E.

doi:10.1002/phy2.277

Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling

Adenylyl cyclase (AC)‐stimulated cAMP is a key mediator of collecting duct (CD) Na and water transport. AC isoforms 3, 4, and 6 are expressed in the CD. Our group demonstrated that AC6, but not AC3, is involved in regulating CD Na and water transport. However, the role of AC4 in such regulation r…