The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Outer membrane vesicles from group B Neisseria meningitidis Δgna33 mutant: Proteomic and immunological comparison with detergent‐derived outer membrane vesicles
Abstract
We compared the proteome of detergent‐derived group B Neisseria meningitidis (MenB) outer membrane vesicles (DOMVs) with the proteome of outer membrane vesicles (m‐OMVs) spontaneously released into culture supernatant by MenB Δ gna33, a mutant in which the gene coding for a lytic transglycosylase homologous to the E. coli MltA was deleted. In total, 138 proteins were identified in DOMVs by 1‐ and 2‐DE coupled with MS; 64% of these proteins belonged to the inner membrane and cytoplasmic compartments. By contrast, most of the 60 proteins of m‐OMVs were classified by PSORT as outer membrane proteins. When tested for their capacity to elicit bactericidal antibodies, m‐OMVs elicited a broad protective activity against a large panel of MenB strains. Therefore, the identification of mutations capable of conferring an OMV‐releasing phenotype in bacteria may represent an attractive approach to study bacterial membrane composition and organization, and to design new efficacious vaccine formulations.
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Cites
Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction
Trotter, C. L., Andrews, N. J., Kaczmarski, E. B., Miller, E., & Ramsay, M. E. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16725-1 · Cited by 571
Maiden, M. C., & Stuart, J. M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08679-8 · Cited by 418
Cited by
Biological Functions and Biogenesis of Secreted Bacterial Outer Membrane Vesicles
Kulp, A., & Kuehn, M. J. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.091208.073413 · Cited by 1,533
Proteomics in gram‐negative bacterial outer membrane vesicles
Lee, E., Choi, D., Kim, K., & Gho, Y. S. (2008) · Mass Spectrometry Reviews · doi:10.1002/mas.20175 · Cited by 339
Metadata
- Authors
- Ferrari, G., Garaguso, I., Adu‐Bobie, J., Doro, F., Taddei, A. R., Biolchi, A., Brunelli, B., Giuliani, M. M., Pizza, M., Norais, N., & Grandi, G.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 6
- Issue
- 6
- Pages
- 1856-1866
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2087469928
- Cited by
- 168
- References
- 2
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ferrari, G., Garaguso, I., Adu‐Bobie, J., Doro, F., Taddei, A. R., Biolchi, A., Brunelli, B., Giuliani, M. M., Pizza, M., Norais, N., & Grandi, G. (2006). Outer membrane vesicles from group B Neisseria meningitidis Δgna33 mutant: Proteomic and immunological comparison with detergent‐derived outer membrane vesicles. PROTEOMICS. https://doi.org/10.1002/pmic.200500164
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