The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses
Abstract
To get more insight into plant cell response to cadmium (Cd) stress, both proteomic and metabolomic “differential display” analyses were performed on Arabidopsis thaliana cells exposed to different concentrations of the toxic chemical. After a 24 h treatment, soluble proteins extracted from untreated and treated cells were separated by 2‐D‐PAGE and image analyses were performed to quantify and compare protein levels. Proteins up‐ and down‐regulated in response to Cd were identified by MS and mapped into specific metabolic pathways and cellular processes, highlighting probable activation of the carbon, nitrogen, and sulfur metabolic pathways. For some of these proteins, Northern blot and RT‐PCR analyses were performed to test transcript accumulation in response to Cd. In parallel, metabolite profiling analyses by LC coupled to ESI MS were initiated to better characterize the metabolic adaptation to the chemical stress. This study revealed that the main variation at the metabolite level came from the presence of six different families of phytochelatins, in A. thaliana cells treated with Cd, whose accumulation increases with Cd concentrations. Taken together these data provide an overview of the molecular and cellular changes elicited by Cd exposure.
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Cites
P HYTOCHELATINS AND M ETALLOTHIONEINS : Roles in Heavy Metal Detoxification and Homeostasis
Cobbett, C., & Goldsbrough, P. (2002) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.53.100301.135154 · Cited by 2,518
Response to cadmium in higher plants
Sanità di Toppi, L., & Gabbrielli, R. (1999) · Environmental and Experimental Botany · doi:10.1016/s0098-8472(98)00058-6 · Cited by 2,252
Randomization, Bootstrap and Monte Carlo Methods in Biology.
Kemp, A. W., & Manly, B. F. J. (1997) · Biometrics · doi:10.2307/2533527 · Cited by 1,927
The Roles of Heat Shock Proteins in Plants
Vierling, E. (1991) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.pp.42.060191.003051 · Cited by 1,439
Phytochelatins and Their Roles in Heavy Metal Detoxification
Cobbett, C. S. (2000) · Plant Physiology · doi:10.1104/pp.123.3.825 · Cited by 1,431
THE FUNCTIONS AND REGULATION OF GLUTATHIONE S-TRANSFERASES IN PLANTS
Marrs, K. A. (1996) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.47.1.127 · Cited by 1,393
The Roles Of Heat Shock Proteins In Plants
Vierling, E. (1991) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.42.1.579 · Cited by 1,319
Phytochelatins: The Principal Heavy-Metal Complexing Peptides of Higher Plants
Grill, E., Winnacker, E.-L., & Zenk, M. H. (1985) · Science · doi:10.1126/science.230.4726.674 · Cited by 1,186
Studies on cadmium toxicity in plants: A review
Das, P., Samantaray, S., & Rout, G. R. (1997) · Environmental Pollution · doi:10.1016/s0269-7491(97)00110-3 · Cited by 1,110
Plant glutathione S -transferases: enzymes with multiple functions in sickness and in health
Edwards, R., Dixon, D. P., & Walbot, V. (2000) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01601-0 · Cited by 931
Cited by
Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants
Clemens, S. (2006) · Biochimie · doi:10.1016/j.biochi.2006.07.003 · Cited by 2,021
Kosová, K., Vítámvás, P., Prášil, I. T., & Renaut, J. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.02.006 · Cited by 852
Responses of Plant Proteins to Heavy Metal Stress—A Review
Hasan, M. K., Cheng, Y., Kanwar, M. K., Chu, X.-Y., Ahammed, G. J., & Qi, Z.-Y. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01492 · Cited by 440
Implications of metal accumulation mechanisms to phytoremediation
Memon, A. R., & Schröder, P. (2009) · Environmental Science and Pollution Research · doi:10.1007/s11356-008-0079-z · Cited by 400
Lankadurai, B. P., Nagato, E. G., & Simpson, M. J. (2013) · Environmental Reviews · doi:10.1139/er-2013-0011 · Cited by 385
Metadata
- Authors
- Sarry, J., Kuhn, L., Ducruix, C., Lafaye, A., Junot, C., Hugouvieux, V., Jourdain, A., Bastien, O., Fievet, J. B., Vailhen, D., Amekraz, B., Moulin, C., Ezan, E., Garin, J., & Bourguignon, J.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2006-03-22
- Volume
- 6
- Issue
- 7
- Pages
- 2180-2198
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2059147982
- Cited by
- 372
- References
- 68
- FWCI
- 25.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sarry, J., Kuhn, L., Ducruix, C., Lafaye, A., Junot, C., Hugouvieux, V., Jourdain, A., Bastien, O., Fievet, J. B., Vailhen, D., Amekraz, B., Moulin, C., Ezan, E., Garin, J., & Bourguignon, J. (2006). The early responses of Arabidopsis thaliana cells to cadmium exposure explored by protein and metabolite profiling analyses. PROTEOMICS. https://doi.org/10.1002/pmic.200500543
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