The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Evaluation of the serum N ‐linked glycome for the diagnosis of cancer and chronic inflammation
Abstract
The identification of serum biomarkers has lead to improvements in the detection and diagnosis of cancer, and combinations of these biomarkers have increased further their sensitivity and specificity. Glycosylation is the most common PTM of secreted proteins and the identification of novel serum glyco‐biomarkers has become a topic of increasing interest because the glycan processing pathways are frequently disturbed in cancer cells. A future goal is to combine current biomarkers with glyco‐biomarkers to yield further improvements. Well characterised N ‐glycosylation changes in the serum glycome of cancer patients include changes in the levels of tri‐ and tetra‐antennary glycan structures, sialyl Lewis X epitopes and agalactosylated bi‐antennary glycans. Several of these glycosylated markers have been linked to chronic inflammatory diseases, promoting questions about the links between inflammation and cancer. In this review, the glycoproteins which display these glycan epitopes, the glycosyl transferases which can generate them, their potential functions and their use as biomarkers are evaluated.
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Citations
Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation
Kaneko, Y., Nimmerjahn, F., & Ravetch, J. V. (2006) · Science · doi:10.1126/science.1129594 · Cited by 1,754
Agalactosyl glycoforms of IgG autoantibodies are pathogenic
Rademacher, T. W., Williams, P., & Dwek, R. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6123 · Cited by 253
Role of Oligosaccharide Residues of IgG1-Fc in FcγRIIb Binding
Mimura, Y., Sondermann, P., Ghirlando, R., Lund, J., Young, S. P., Goodall, M., & Jefferis, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107478200 · Cited by 236
Cited by
High-sensitivity Analytical Approaches for the Structural Characterization of Glycoproteins
Alley, W. R., Mann, B. F., & Novotny, M. V. (2013) · Chemical Reviews · doi:10.1021/cr3003714 · Cited by 310
Zhong, X., Chen, Z., Snovida, S., Liu, Y., Rogers, J. C., & Li, L. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01835 · Cited by 92
Metadata
- Authors
- Arnold, J. N., Saldova, R., Hamid, U. M. A., & Rudd, P. M.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2008-08
- Volume
- 8
- Issue
- 16
- Pages
- 3284-3293
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2050848743
- Cited by
- 307
- References
- 4
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arnold, J. N., Saldova, R., Hamid, U. M. A., & Rudd, P. M. (2008). Evaluation of the serum N ‐linked glycome for the diagnosis of cancer and chronic inflammation. PROTEOMICS. https://doi.org/10.1002/pmic.200800163
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