Unraveling the S ‐nitrosoproteome: Tools and strategies
Abstract
One of the major tasks to be accomplished in the postgenomic era is the characterization of PTMs in proteins. The S ‐nitrosation of protein thiols is a redox‐based PTM that modulating enzymatic activity, subcellular localization, complex formation, and degradation of proteins, largely contributes to the complexity of cellular proteomes. Although the detection of S ‐nitrosated proteins is problematical due to the lability of S ‐nitrosothiols, with the improvement of molecular tools an increasing range of proteins has been shown to undergo S ‐nitrosation. We here review recent proteomic approaches for the systematic assessment of potential targets for protein S ‐nitrosation. The development of new analytical methods and strategies over the past several years now allows us to investigate the nitrosoproteome on a global scale.
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Well over 100 proteins have been shown to be S-nitrosated.
“Well over 100 proteins have been shown to be S-nitrosated, and as the list of S-nitrosated proteins grows, the potential relevance of this modification and other NO-induced protein modifications in redox biology and signaling is of increasing interest (61, 62).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [61]
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References 90 · Cited by 35
- Authors
- López‐Sánchez, L. M., Muntané, J., de la Mata, M., & Rodríguez‐Ariza, A.
- Affiliations
- Hospital Universitario Reina Sofía (ES)
- Corresponding author
- Rodríguez‐Ariza, Antonio
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2009-01-21
- Volume
- 9
- Issue
- 4
- Pages
- 808-818
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2016468134
- Cited by
- 35
- References
- 90
- Citations by year
- 2024: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2014: 1 · 2013: 4 · 2012: 8
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PROTEOMICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- S-nitrosylation, S-nitrosothiols, post-translational modification, protein thiols, redox signaling
- MeSH terms
- Animals, Biotin, Cell Communication, Cysteine, Humans, Nitric Oxide, Oxidation-Reduction, Protein Processing, Post-Translational, Proteins, Sulfhydryl Compounds, Nitrosation, S-Nitrosothiols, Proteomics, Mice, Rats
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