Proteomic analysis of the microenvironment of developing oocytes
Abstract
We utilized a setup based on extensive pre‐fractionation of proteolytic peptides and nanoflow reversed‐phase LC‐MS/MS to identify the (sub)proteome of human follicular fluid (FF). In this in‐depth screen, 246 specific proteins were identified, the majority of which are involved in coagulation‐ and immune‐response pathways. Our aim is to define a set of FF protein markers, which could predict oocyte quality.
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There are a large number of renin original substrates AGT in hFF with healthy oocytes, and the content ranks 11th-14th.
“There are a large number of renin original substrates AGT in hFF with healthy oocytes [32, 33], and the content ranks 11th–14th [34].”
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Proteomic analysis of human follicular fluid from fertile women
Zamah, A. M., Hassis, M. E., Albertolle, M. E., & Williams, K. E. (2015) · Clinical Proteomics · doi:10.1186/s12014-015-9077-6 · Cited by 132 · see citing works
Wei, L., Bo, L., Luo, C., Yin, N., Jiang, W., Qian, F., Zhou, A., Lu, X., Guo, H., & Mao, C. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03997-6 · Cited by 11 · see citing works
“There are a large number of renin original substrates AGT in hFF with healthy oocytes [32, 33], and the content ranks 11th–14th [34].”
Background
- Authors
- Twigt, J., Steegers‐Theunissen, R. P., Bezstarosti, K., & Demmers, J. A. A.
- Affiliations
- Erasmus MC (NL)
- Department of Obstetrics and Gynecology Erasmus University Medical Center Rotterdam The Netherlands
- Corresponding author
- Demmers, Jeroen A. A.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2012-05
- Volume
- 12
- Issue
- 9
- Pages
- 1463-1471
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2021527386
- Cited by
- 58
- References
- 0
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 2 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 4 · 2013: 7
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PROTEOMICS (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- follicular fluid, oogenesis, oocyte microenvironment, coagulation factors, immune response proteins, protein biomarkers
- MeSH terms
- Female, Humans, Isoelectric Focusing, Oocytes, Peptide Fragments, Follicular Fluid, Proteome, Proteomics, Tandem Mass Spectrometry, Chromatography, Reverse-Phase, Cellular Microenvironment
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