Why do patients choose (not) to participate in an exercise trial during adjuvant chemotherapy for breast cancer?
Open accessAbstract
Objective: Only between 25% and 50% of patients invited to participate in clinical trial‐based physical exercise programs during cancer treatment agree to do so. The purpose of this study was to identify factors associated significantly with the decision (not) to participate in a randomized controlled trial of physical exercise during adjuvant chemotherapy for breast cancer. Methods: Based on questionnaire data, we compared trial participants and non‐participants on a range of sociodemographic, clinical health‐related, practical, behavioral, and attitudinal variables. Results: Two hundred thirty of 524 patients agreed to participate in the trial (44%). The 294 (56%) non‐participants indicated that they wanted to exercise on their own or that they did not wish to exercise in the context of a trial. Those who preferred to exercise on their own were relatively similar to trial participants but were more likely to be in the maintenance exercise stage. Those non‐participants who did not wish to exercise had a significantly lower level of education, were less likely to be working, reported more fatigue and lower health‐related quality of life, had lower sense of self‐efficacy, more negative attitudes towards exercise, less social support, and perceived fewer benefits and more barriers to exercising during treatment than trial participants. Conclusion: Minimizing practical barriers to participation, providing educational materials on the potential benefits of exercise, and giving adequate professional and social network encouragement may increase the number of patients willing to exercise during treatment and to participate in such studies. Copyright © 2015 John Wiley & Sons, Ltd.
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50% of survivors refuse to engage in physical activity.
“This is what leads to 50% of survivors refusing to engage in physical activity.”
From Empowerment in the treatment of fatigue in breast cancer patients (2021) · cites this paper as [25]
The Abstract reports that 56% of breast cancer patients invited to an exercise trial during chemotherapy did not participate. But non-participation is not refusal to engage in physical activity: some wanted to exercise on their own, and the Self-reported reasons for non-participation section reports that 18% of non-participants said they did not want to exercise at all. The paper does not establish that 50% of survivors refuse physical activity. (LLM, conf=0.89)
Experimental — accuracy not yet measuredFactors contributing to reluctance to engage in physical activity include level of education, quality of life, low self-efficacy, and little social support.
“Several factors contribute to this reluctance, namely: level of education, quality of life and low self-efficacy and little social support [24, 25].”
From Empowerment in the treatment of fatigue in breast cancer patients (2021) · cites this paper as [25]
The Sociodemographic and clinical variables section reports lower education among patients who did not want to exercise, and the discussion on p. 968 reports lower health-related quality of life, exercise self-efficacy, and social support in that group. The study identifies associations with declining an exercise trial during breast-cancer chemotherapy; it does not establish that these factors cause reluctance to engage in physical activity generally. (LLM, conf=0.86)
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References 34 · Cited by 95
Research works printed but not linked: 1
- Courneya KS, Friedenreich CM. Utility of the theory of planned behavior for understanding exercise during breast cancer treatment. Psycho-Oncology 1999;8:112-122.
- Authors
- van Waart, H., van Harten, W. H., Buffart, L. M., Sonke, G. S., Stuiver, M. M., & Aaronson, N. K.
- Affiliations
- Division of Psychosocial Research and Epidemiology The Netherlands Cancer Institute Amsterdam The Netherlands
- Amsterdam Public Health (NL)
- The Netherlands Cancer Institute (NL)
- Corresponding author
- Aaronson, Neil K.
- Venue
- Psycho-Oncology
- Publisher
- Wiley
- Published
- 2015-08-17
- Volume
- 25
- Issue
- 8
- Pages
- 964-970
- ISSN
- 1057-9249 (ISSN-L)
- 1099-1611
- OpenAlex
- W2106228748
- Cited by
- 95
- References
- 34
- Citations by year
- 2025: 6 · 2024: 15 · 2023: 9 · 2022: 12 · 2021: 7 · 2020: 8 · 2019: 12 · 2018: 11 · 2017: 10 · 2016: 5
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Psycho-Oncology (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Twente Research Information (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- University of Twente Research Information (submittedVersion)
- Funders
- Alpe d'HuZes/KWF Fund (2009-4299)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- breast cancer, adjuvant chemotherapy, barriers to exercise, self-efficacy, social support, health-related quality of life, fatigue, exercise education, patient decision-making
- MeSH terms
- Aged, Attitude to Health, Breast Neoplasms, Female, Humans, Middle Aged, Quality of Life, Surveys and Questionnaires, Social Support, Exercise, Chemotherapy, Adjuvant, Self Efficacy
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