The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Protamine-Capped Mesoporous Silica Nanoparticles for Biologically Triggered Drug Release
Abstract
The fabrication of a mesoporous silica nanoparticle (MSN)−protamine hybrid system (MSN−PRM) is reported that selectively releases drugs in the presence of specific enzyme triggers present in the proximity of cancer cells. The enzyme trigger involved is a protease called trypsin, which is overexpressed in certain specific pathological conditions, such as inflammation and cancer. Overexpression of trypsin is known to be associated with invasion, metastasis, and growth in several cancers, such as leukemia, colon cancer, and colorectal cancer. The current system (MSN–PRM) consists of an MSN support in which mesopores are capped with an FDA‐approved peptide drug protamine, which effectively blocks the outward diffusion of the drug molecules from the mesopores of the MSNs. On exposure to the enzyme trigger, the protamine cap disintegrates, opening up the molecular gates and releasing the entrapped drug molecules. The system exhibits minimal premature release in the absence of the trigger and selectively releases the encapsulated drugs in the presence of the proteases secreted by colorectal cancer cells. The ability of the MSN–PRM particles to deliver anticancer drugs to colorectal cancer cells has also been demonstrated. The hydrophobic drug is released into cancer cells subsequent to disintegration of the protamine cap, resulting in cell death. Drug‐induced cell death in colorectal cancer cells is significantly enhanced when the hydrophobic drug that is known to degrade in aqueous environments is encapsulated in the MSN–PRM system in comparison to the free drug (P < 0.05). The system, which shows good biocompatibility and selective drug release, is a promising platform for cancer specific drug delivery.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,891
Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal, B. B., Kumar, A. J., & Bharti, A. C. (2003) · PubMed · Cited by 2,550
Stability of curcumin in buffer solutions and characterization of its degradation products
Wang, Y., Pan, M., Cheng, A., Lin, L., Ho, Y., Hsieh, C., & Lin, J. (1997) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(96)02024-9 · Cited by 1,709
Lai, C., Trewyn, B. G., Jeftinija, D. M., Jeftinija, K., Xu, S., Jeftinija, S., & Lin, V. S. ‐. (2003) · Journal of the American Chemical Society · doi:10.1021/ja028650l · Cited by 1,679
Mesoporous silica nanoparticles deliver DNA and chemicals into plants
Torney, F., Trewyn, B. G., Lin, V. S. ‐., & Wang, K. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.108 · Cited by 1,484
Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica
Mal, N. K., Fujiwara, M., & Tanaka, Y. (2003) · Nature · doi:10.1038/nature01362 · Cited by 1,096
Zhu, Y., Shi, J., Shen, W., Dong, X., Feng, J., Ruan, M., & Li, Y. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501500 · Cited by 1,011
Giri, S., Trewyn, B. G., Stellmaker, M. P., & Lin, V. S. ‐. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501819 · Cited by 997
A Polyamidoamine Dendrimer-Capped Mesoporous Silica Nanosphere-Based Gene Transfection Reagent
Radu, D. R., Lai, C., Jeftinija, K., Rowe, E., Jeftinija, S., & Lin, V. S. ‐. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046275m · Cited by 840
Chen, Y., Chen, H., & Shi, J. (2013) · Advanced Materials · doi:10.1002/adma.201205292 · Cited by 733
Research works printed but not linked: 3
- Xu C., 2013, Adv. Healthc. Mater.
- Koivunen E., 1991, Cancer Res., 51, 2107
- Aggarwal B. B., 2003, Anticancer Res., 23, 363
Cited by
Sorted by citations
Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances
Narayan, R., Nayak, U. Y., Raichur, A. M., & Garg, S. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030118 · Cited by 987
Self-citationMesoporous Silica Nanoparticles for Drug Delivery
Manzano, M., & Vallet‐Regí, M. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201902634 · Cited by 974
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 606
Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?
Vallet‐Regí, M., Schüth, F., Lozano, D., Colilla, M., & Manzano, M. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00659b · Cited by 537
Gated Materials for On-Command Release of Guest Molecules
Aznar, E., Oroval, M., Pascual, L., Murguía, J. R., Martínez‐Máñez, R., & Sancenón, F. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00456 · Cited by 497
Metadata
- Authors
- Radhakrishnan, K., Gupta, S., Gnanadhas, D. P., Ramamurthy, P. C., Chakravortty, D., & Raichur, A. M.
- Affiliations
- Indian Institute of Science Bangalore (IN)
- Department of Microbiology and Cell Biology Indian Institute of Science Bangalore 560012 India
- University of Johannesburg (ZA)
- Corresponding author
- Raichur, Ashok M.
- ORCID
- Venue
- Particle & Particle Systems Characterization
- Publisher
- Wiley
- Published
- 2013-10-22
- Volume
- 31
- Issue
- 4
- Pages
- 449-458
- ISSN
- 0934-0866 (ISSN-L)
- 1521-4117
- OpenAlex
- W1998103515
- Cited by
- 50
- References
- 41
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 9 · 2014: 2
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Particle & Particle Systems Characterization (publishedVersion)
- NOT FOUND REPOSITORY (Indian Institute of Science Bangalore) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
- Physical Sciences › Earth and Planetary Sciences › Geochemistry and Petrology › Clay minerals and soil interactions
- Keywords
- mesoporous silica nanoparticles, protamine, enzyme-responsive drug release, trypsin, colorectal cancer, anticancer drug delivery, hydrophobic drug encapsulation, cancer cell death, biocompatibility
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Protamine-Capped Mesoporous Silica Nanoparticles for Biologically Triggered Drug Release. https://app.cochat.ai/papers/10.1002/ppsc.201300219
- The paper
- Radhakrishnan, K., Gupta, S., Gnanadhas, D. P., Ramamurthy, P. C., Chakravortty, D., & Raichur, A. M. (2014). Protamine-Capped Mesoporous Silica Nanoparticles for Biologically Triggered Drug Release. Particle & Particle Systems Characterization. https://doi.org/10.1002/ppsc.201300219
