Airway clearance and exercise for people with cystic fibrosis: balancing longevity with life
Open accessAbstract
Airway clearance has been an integral part of cystic fibrosis (CF) care for almost as long as CF has been identified as a condition. From diagnosis as a neonate through to end-of-life care, airway clearance is an everyday aspect of life, adding a considerable treatment burden to the lives of people with CF. There are many different techniques used for airway clearance which have evolved over time with an aim to improve effectiveness, support adherence and, more recently, to consider the impact of burden. A popular thought is whether airway clearance could be replaced by exercise. With new precision therapies in the form of CFTR modulators available, the CF landscape is rapidly changing, raising the question of whether certain treatments are needed at all. Depending on factors such as CFTR mutation, age, and pre-existing lung damage before starting a CFTR modulator, individuals with CF may need different levels of intensity and type of maintenance treatment. Precision medicine is likely to lead to the need for increased precision and individualized management around other maintenance therapies such as airway clearance.
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The results of the included trial suggest that there are other ways of reducing perceived treatment burden other than withdrawing treatments or replacing treatments with those perceived to be less burdensome.
“the results of the included trial suggest that there are other ways of reducing perceived treatment burden other than withdrawing treatments or replacing treatments with those perceived to be less burdensome (Rowbotham 2022).”
From Psychological interventions for improving adherence to inhaled therapies in people with cystic fibrosis (2023) · cites this paper as Rowbotham 2022
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References 83 · Cited by 16
Research works printed but not linked: 2
- Trust ACF. Standards of Care and Good Clinical Practice for the Physiotherapy Management of Cystic Fibrosis -4th edition. In:2020.
- Wildman MJ. Effectiveness of a self-management intervention to support treatment adherence in adults with cystic fibrosis: a randomised controlled trial.. Pediatric Pulmonology. 2020;55:S265-S266.
- Authors
- Rowbotham, N. J., & Daniels, T. E.
- Affiliations
- University of Nottingham (GB)
- York St John University (GB)
- Corresponding author
- Rowbotham, Nicola J.
- Venue
- Pediatric Pulmonology
- Publisher
- Wiley
- Published
- 2021-11-02
- Volume
- 57
- Issue
- S1
- Pages
- S50-S59
- ISSN
- 1099-0496 (ISSN-L)
- 8755-6863
- OpenAlex
- W3207295126
- Cited by
- 16
- References
- 83
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 3
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Pediatric Pulmonology (publishedVersion)
- PubMed (publishedVersion)
- Repository@Nottingham (University of Nottingham) (acceptedVersion, other-oa)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by-nc-nd)
- Research at York St John (York St John University) (submittedVersion)
- Funders
- National Institute for Health and Care Research (ACF-2013-12-007)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- cystic fibrosis, airway clearance, exercise therapy, CFTR modulators, treatment burden, medication adherence, maintenance therapy, individualized management, lung function
- MeSH terms
- Cystic Fibrosis, Humans, Infant, Newborn, Longevity, Mutation, Cystic Fibrosis Transmembrane Conductance Regulator, Precision Medicine
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