The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Structural basis of substrate specificity in the serine proteases
Open accessAbstract
Structure‐based mutational analysis of serine protease specificity has produced a large database of information useful in addressing biological function and in establishing a basis for targeted design efforts. Critical issues examined include the function of water molecules in providing strength and specificity of binding, the extent to which binding subsites are interdependent, and the roles of polypeptide chain flexibility and distal structural elements in contributing to specificity profiles. The studies also provide a foundation for exploring why specificity modification can be either straightforward or complex, depending on the particular system.
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Citations
Cites
Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Hydrolysis of a peptide bond in neutral water
Kahne, D., & Still, W. C. (1988) · Journal of the American Chemical Society · doi:10.1021/ja00230a041 · Cited by 176
Ventralizing signal determined by protease activation in Drosophila embryogenesis
Smith, C. L., & DeLotto, R. (1994) · Nature · doi:10.1038/368548a0 · Cited by 75
Siezen, R. J., Bruinenberg, P. G., Vos, P., Alen-Boerrigter, I. V., Nijhuis, M., Alting, A. C., Exterkate, F. A., & Vos, W. M. D. (1993) · "Protein Engineering, Design and Selection" · doi:10.1093/protein/6.8.927 · Cited by 40
Cited by
Modeling of loops in protein structures
Fiser, A., Do, R. K. G., & Šali, A. (2000) · Protein Science · doi:10.1110/ps.9.9.1753 · Cited by 2,116
Subtilases: the superfamily of subtilisin-like serine proteases.
Siezen, R. J., & Leunissen, J. A. M. (1997) · Protein Science · doi:10.1002/pro.5560060301 · Cited by 896
Folding funnels, binding funnels, and protein function
Tsai, C., Kumar, S., Ma, B., & Nussinov, R. (1999) · Protein Science · doi:10.1110/ps.8.6.1181 · Cited by 648
Clausen, T., Southan, C., & Ehrmann, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00658-5 · Cited by 640
The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease
Long, J. Z., & Cravatt, B. F. (2011) · Chemical Reviews · doi:10.1021/cr200075y · Cited by 425
Metadata
- Authors
- Perona, J. J., & Craik, C. S.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 1995-03
- Volume
- 4
- Issue
- 3
- Pages
- 337-360
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- OpenAlex
- W2004091546
- Cited by
- 837
- References
- 4
- FWCI
- 13.52
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Structural basis of substrate specificity in the serine proteases. https://app.cochat.ai/papers/10.1002/pro.5560040301
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- Perona, J. J., & Craik, C. S. (1995). Structural basis of substrate specificity in the serine proteases. Protein Science. https://doi.org/10.1002/pro.5560040301
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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