The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Principles of protein folding — A perspective from simple exact models
Open accessAbstract
General principles of protein structure, stability, and folding kinetics have recently been explored in computer simulations of simple exact lattice models. These models represent protein chains at a rudimentary level, but they involve few parameters, approximations, or implicit biases, and they allow complete explorations of conformational and sequence spaces. Such simulations have resulted in testable predictions that are sometimes unanticipated: The folding code is mainly binary and delocalized throughout the amino acid sequence. The secondary and tertiary structures of a protein are specified mainly by the sequence of polar and nonpolar monomers. More specific interactions may refine the structure, rather than dominate the folding code. Simple exact models can account for the properties that characterize protein folding: two‐state cooperativity, secondary and tertiary structures, and multistage folding kinetics —fast hydrophobic collapse followed by slower annealing. These studies suggest the possibility of creating “foldable” chain molecules other than proteins. The encoding of a unique compact chain conformation may not require amino acids; it may require only the ability to synthesize specific monomer sequences in which at least one monomer type is solvent‐averse.
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Cites
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Cited by
From Levinthal to pathways to funnels
Dill, K. A., & Chan, H. S. (1997) · Nature Structural & Molecular Biology · doi:10.1038/nsb0197-10 · Cited by 2,293
Self-citationTHEORY OF PROTEIN FOLDING: The Energy Landscape Perspective
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Self-citationBayesian statistical analysis of protein side‐chain rotamer preferences
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Folding funnels and binding mechanisms
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Metadata
- Authors
- Dill, K. A., Bromberg, S., Yue, K., Chan, H. S., Fiebig, K. M., Yee, D. P., & Thomas, P. D.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 1995-04
- Volume
- 4
- Issue
- 4
- Pages
- 561-602
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- OpenAlex
- W2114899912
- Cited by
- 1,525
- References
- 9
- FWCI
- 35.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dill, K. A., Bromberg, S., Yue, K., Chan, H. S., Fiebig, K. M., Yee, D. P., & Thomas, P. D. (1995). Principles of protein folding — A perspective from simple exact models. Protein Science. https://doi.org/10.1002/pro.5560040401
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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