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Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: The current state of affairs
Open accessAbstract
The first identified covalent flavoprotein, a component of mammalian succinate dehydrogenase, was reported 42 years ago. Since that time, more than 20 covalent flavoenzymes have been described, each possessing one of five modes of FAD or FMN linkage to protein. Despite the early identification of covalent flavoproteins, the mechanisms of covalent bond formation and the roles of the covalent links are only recently being appreciated. The main focus of this review is, therefore, one of mechanism and function, in addition to surveying the types of linkage observed and the methods employed for their identification. Case studies are presented for a variety of covalent flavoenzymes, from which general findings are beginning to emerge.
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Cited by
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van Berkel, W. J. H., Kamerbeek, N. M., & Fraaije, M. W. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.03.044 · Cited by 671
Function and Structure of Complex II of the Respiratory Chain
Cecchini, G. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161700 · Cited by 556
Xie, H., Vucetic, S., Iakoucheva, L. M., Oldfield, C. J., Dunker, A. K., Obradovic, Z., & Uversky, V. N. (2007) · Journal of Proteome Research · doi:10.1021/pr060394e · Cited by 382
Progress in understanding structure-function relationships in respiratory chain complex II.
Ackrell, B. A. C. (2000) · FEBS Letters · doi:10.1016/s0014-5793(99)01749-4 · Cited by 144
Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Sutherland, E., Harding, C. J., du Monceau de Bergendal, T., Florence, G. J., Ackermann, K., Bode, B. E., Synowsky, S., Sundaramoorthy, R., & Czekster, C. M. (2025) · Nature Communications · doi:10.1038/s41467-025-56127-y · Cited by 2
Metadata
- Authors
- Mewies, M., McIntire, W. S., & Scrutton, N. S.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 7
- Issue
- 1
- Pages
- 7-20
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- OpenAlex
- W2161214077
- Cited by
- 221
- References
- 0
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: The current state of affairs. https://app.cochat.ai/papers/10.1002/pro.5560070102
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- Mewies, M., McIntire, W. S., & Scrutton, N. S. (1998). Covalent attachment of flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) to enzymes: The current state of affairs. Protein Science. https://doi.org/10.1002/pro.5560070102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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