The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Effects of bufalin and cinobufagin on the proliferation of androgen dependent and independent prostate cancer cells
Abstract
Background: Cardiac glycosides may induce oncolytic effects in cancers. This study was to evaluate bufalin and cinobufagin effects on the proliferation of prostate cancer cell lines named LNCaP, DU145, and PC3. Methods: Cell proliferation was measured by MTT assay. The cytotoxic effects were determined by lactate dehydrogenase measurements. The intracellular calcium concentration ([Ca 2+]i) was measured by a dual‐wavelength spectrometer system. TUNEL assay and flow cytometry were performed to measure percentage of apoptotic cells. A colorimetric assay was to measure caspases activities. Results: Bufalin and cinobufagin inhibited proliferation of cancer cells at doses of 0.1, 1, or 10 μM after 2–4 days of culture. Cytotoxicity of bufalin and cinobufagin on the DU145 and LNCaP cells was dose‐dependent. Bufalin or cinobufagin increased [Ca 2+]i and apoptosis in cancer cells after a 24‐hr culture as well as caspase 3 activities in DU145 and PC3 cells and caspase 9 activities in LNCaP cells. Conclusions: Bufalin and cinobufagin may inhibit the proliferation of prostate cancer cell lines associated with sustained elevation of the [Ca 2+]i and that of apoptosis. Prostate 54: 112–124, 2003. © 2002 Wiley‐Liss, Inc.
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Cites
A Controlled Trial of Leuprolide with and without Flutamide in Prostatic Carcinoma
Crawford, E. D., Eisenberger, M. A., McLeod, D. G., Spaulding, J. T., Benson, R., Dorr, F. A., Blumenstein, B. A., Davis, M. A., & Goodman, P. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908173210702 · Cited by 1,464
Stein (2000) · doi:10.1054/mehy.1999.0985 · Cited by 171
Is digitalis a therapy for breast carcinoma?
Stenkvist, B. (1999) · Oncology Reports · doi:10.3892/or.6.3.493 · Cited by 160
Cited by
Novel therapeutic applications of cardiac glycosides
Prassas, I., & Diamandis, E. P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2682 · Cited by 673
Cardiotonic steroids on the road to anti-cancer therapy
Mijatovic, T., Van Quaquebeke, E., Delest, B., Debeir, O., Darro, F., & Kiss, R. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.06.002 · Cited by 317
Meng, Z., Yang, P., Shen, Y., Bei, W., Zhang, Y., Ge, Y., Newman, R. A., Cohen, L., Liu, L., Thornton, B., et al. (2009) · Cancer · doi:10.1002/cncr.24602 · Cited by 289
Zhang, Y., Dong, Y., Melkus, M. W., Yin, S., Tang, S.-N., Jiang, P., Pramanik, K., Wu, W., Kim, S., Ye, M., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-1296 · Cited by 55
Zheng, Y., He, Z., Su, Z., Wang, H., Jiang, X., Fang, X., Lu, S., & Li, Y. (2023) · Cell Biology International · doi:10.1002/cbin.12021 · Cited by 10
Metadata
- Authors
- Yeh, J., Huang, W. J., Kan, S., & Wang, P. S.
- Venue
- The Prostate
- Publisher
- Wiley
- Published
- 2002-12-20
- Volume
- 54
- Issue
- 2
- Pages
- 112-124
- ISSN
- 0270-4137 (ISSN-L)
- 1097-0045
- OpenAlex
- W2048719138
- Cited by
- 205
- References
- 3
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
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