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Cited by 110Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and TreatmentHormonal and reproductive studies

The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.

Familial factors affecting prostatic cancer risk and plasma sex-steroid levels

Wayne Meikle, A., Smith, Joseph A., West, Dee W.·1985·The Prostate
DOI 10.1002/pros.2990060202
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Abstract

Whether familial factors affect the frequency of prostatic cancer and the plasma content of sex‐steroids was investigated. Brothers (n = 257) of probands (n = 150) diagnosed with prostatic cancer before age 62 years had a fourfold higher risk for developing the disease than men in the general population in the State of Utah and their brothers‐in‐law (n = 202). Familial factors markedly affected the plasma content of sex steroids (testosterone, dihydro‐testosterone, the ratio of testosterone to DHT, sex‐hormone binding globulin, and the free fraction of testosterone) in nonendocrinologically treated probands and their brothers and sons and in normal men in the general populations. Index cases and their brothers and sons had a significantly lower mean plasma testosterone content than controls of comparable age. Preliminary data suggest that the metabolic clearance rate of testosterone and the conversion ratio of testosterone to estradiol are relatively high in probands. The observations indicate that familial factors are potent risk factors for the development of prostatic cancer. They also suggest that plasma androgen values in families with prostatic cancer cluster in the lower range of normal and that plasma sex‐steroid content is more similar in each brothers with or without prostatic cancer than among nonbrothers.

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Crossref · 10.1002/pros.2990060202

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Research works printed but not linked: 5

  1. Moore RA, 1944, Benign hypertrophy and a carcinoma of the prostate. Occurrence and experimental production in animals, Surgery, 16, 152
  2. Silverberg E, 1977, Cancer statistics, Cancer, 27, 26
  3. Cannon L, 1982, Genetic epidemiology of prostate cancer in the Utah Mormon Genealogy, Cancer Surv, 1, 47
  4. Lipsett MB, 1977, The Human Testis, 407
  5. Heyns W, 1977, The steroid‐binding β‐globulin of human plasma, Adv Steroid Biochem Pharmacol, 6, 59

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Metadata

Authors
Wayne Meikle, A., Smith, J. A., & West, D. W.
Affiliations
University of Utah (US)
Venue
The Prostate
Publisher
Wiley
Published
1985-01
Volume
6
Issue
2
Pages
121-128
ISSN
  • 0270-4137 (ISSN-L)
  • 1097-0045
DOI
10.1002/pros.2990060202
OpenAlex
W1976692247
Cited by
110
References
49
Citations by year
2019: 1 · 2018: 2 · 2016: 2 · 2015: 1 · 2012: 2
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7870 d)
Locations
  • The Prostate (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (CA-25031)
  • National Center for Research Resources (RR-64)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
  • Health Sciences › Medicine › Urology › Prostate Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
prostate cancer, familial risk, plasma sex steroids, testosterone, dihydrotestosterone, sex hormone-binding globulin, free testosterone, androgen metabolism, Utah
MeSH terms
Adult, Aged, Humans, Male, Metabolic Clearance Rate, Middle Aged, Prostatic Neoplasms, Risk, Gonadal Steroid Hormones, Dihydrotestosterone, Testosterone

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