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Comparative modeling methods: Application to the family of the mammalian serine proteases
Abstract
Comparative modeling methods are described that can be used to construct a three‐dimensional model structure of a new protein from knowledge of its sequence and of the experimental structure and sequences of other members of its homology family. The methods are illustrated with the mammalian serine protease family, for which seven experimental structures have been reported in the literature, and the sequence for over 35 different protein members of the family are available. The strategy for modeling these proteins is presented, and criteria are developed for determining and assigning the reliability of the modeled structure. Criteria are described that are specially designed to help detect cases in which it is likely that the local structure diverges significantly from the usual conformation of the family.
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Cited by
Comparative Protein Structure Modeling of Genes and Genomes
Martí-Renom, M. A., Stuart, A. C., Fiser, A., Sánchez, R., Melo, F., & Šali, A. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.291 · Cited by 3,169
Subtilases: the superfamily of subtilisin-like serine proteases.
Siezen, R. J., & Leunissen, J. A. M. (1997) · Protein Science · doi:10.1002/pro.5560060301 · Cited by 896
The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution
Wang, Z., Harkins, P. C., Ulevitch, R. J., Han, J., Cobb, M. H., & Goldsmith, E. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2327 · Cited by 275
Metadata
- Authors
- Greer, J.
- Venue
- Proteins: Structure, Function, and Bioinformatics
- Publisher
- Wiley
- Published
- 1990-01
- Volume
- 7
- Issue
- 4
- Pages
- 317-334
- ISSN
- 0887-3585 (ISSN-L)
- 1097-0134
- OpenAlex
- W2152873608
- Cited by
- 383
- References
- 0
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greer, J. (1990). Comparative modeling methods: Application to the family of the mammalian serine proteases. Proteins: Structure, Function, and Bioinformatics. https://doi.org/10.1002/prot.340070404
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