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Thermodynamics of ubiquitin unfolding
Abstract
The energetics of ubiquitin unfolding have been studied using differential scanning microcalorimetry. For the first time it has been shown directly that the enthalpy of protein unfolding is a nonlinear function of temperature. Thermodynamic parameters of ubiquitin unfolding were correlated with the structure of the protein. The enthalpy of hydrogen bonding in ubiquitin was calculated and compared to that obtained for other proteins. It appears that the energy of hydrogen bonding correlates with the average length of the hydrogen bond in a given protein structure. © 1994 John Wiley & Sons, Inc.
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Citations
Cited by
Gómez, J., Hilser, V. J., Xie, D., & Freire, E. (1995) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.340220410 · Cited by 428
Macromolecular Crowding and Protein Stability
Wang, Y., Sarkar, M., Smith, A. E., Krois, A. S., & Pielak, G. J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305300m · Cited by 346
Atomic-level description of ubiquitin folding
Piana, S., Lindorff-Larsen, K., & Shaw, D. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218321110 · Cited by 326
Protein Stabilization by Macromolecular Crowding through Enthalpy Rather Than Entropy
Senske, M., Törk, L., Born, B., Havenith, M., Herrmann, C., & Ebbinghaus, S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja503205y · Cited by 284
Muñoz, V., & Serrano, L. (1995) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.0024 · Cited by 251
Metadata
- Authors
- Wintrode, P. L., Makhatadze, G. I., & Privalov, P. L.
- Venue
- Proteins: Structure, Function, and Bioinformatics
- Publisher
- Wiley
- Published
- 1994-03
- Volume
- 18
- Issue
- 3
- Pages
- 246-253
- ISSN
- 0887-3585 (ISSN-L)
- 1097-0134
- OpenAlex
- W2122680286
- Cited by
- 185
- References
- 0
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wintrode, P. L., Makhatadze, G. I., & Privalov, P. L. (1994). Thermodynamics of ubiquitin unfolding. Proteins: Structure, Function, and Bioinformatics. https://doi.org/10.1002/prot.340180305
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