Analysis of FK506, timcodar (VX‐853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation

Hinds, Terry D.; Stechschulte, Lance A.; Elkhairi, Fadel; Sanchez, Edwin R.

doi:10.1002/prp2.76

Analysis of FK506, timcodar (VX‐853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation

The immunosuppressive ligand FK 506 and the FK 506‐binding protein FKBP 52 are stimulatory to glucocorticoid receptor ( GR ) activity. Here, we explore the underlying mechanism by comparing GR activity and phosphorylation status in response to FK 506 and the novel nonimmunosuppressive ligand timc…