Synthesis and testing of novel alternative oxidase (AOX) inhibitors with antifungal activity against Moniliophthora perniciosa (Stahel), the causal agent of witches' broom disease of cocoa, and other phytopathogens

Barsottini, Mario RO; Pires, Bárbara A; Vieira, Maria L; Pereira, José GC; Costa, Paulo CS; Sanitá, Jaqueline; Coradini, Alessandro; Mello, Fellipe; Marschalk, Cidnei; Silva, Eder M; Paschoal, Daniele; Figueira, Antonio; Rodrigues, Fábio HS; Cordeiro, Artur T; Miranda, Paulo CML; Oliveira, Paulo SL; Sforça, Maurício L; Carazzolle, Marcelo F; Rocco, Silvana A; Pereira, Gonçalo AG

doi:10.1002/ps.5243

Synthesis and testing of novel alternative oxidase (AOX) inhibitors with antifungal activity against Moniliophthora perniciosa (Stahel), the causal agent of witches' broom disease of cocoa, and other phytopathogens

Background Moniliophthora perniciosa (Stahel) Aime & Phillips‐Mora is the causal agent of witches' broom disease (WBD) of cocoa ( Theobroma cacao L .) and a threat to the chocolate industry. The membrane‐bound enzyme alternative oxidase (AOX) is critical for M. perniciosa virulence and resistance…