Restoration of leptin responsiveness in diet‐induced obese mice using an optimized leptin analog in combination with exendin‐4 or FGF21

Müller, Timo D., Sullivan, Lorraine M., Habegger, Kirk, Yi, Chun‐Xia, Kabra, Dhiraj, Grant, Erin, Ottaway, Nickki, Krishna, Radha +11 more·2012·Journal of Peptide Science
DOI 10.1002/psc.2408

Cited by (157)

Items 101–157 of 157

  1. Effect of branched-chain amino acids on food intake and indicators of hunger and satiety- a narrative summary
    Brianna Lueders, Bradley C. Kanney, Martina J. Krone, Nicholas P. Gannon, Roger A. Vaughan · 2022 · Human Nutrition & Metabolism
  2. The correlation between obesity and leptin signaling pathways
    Miriam Jasim Shehab, Sarah T. Al-Mofarji, Batool Mutar Mahdi, Rasha Sadeq Ameen, Mohammed Mahdi Al–Zubaidi · 2025 · Cytokine
  3. Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice
    Mehdi Labyb, Claire Chrétien, Aurélie Caillon, Françoise Rohner‐Jeanrenaud, Jordi Altirriba · 2018 · International Journal of Molecular Sciences
  4. Is “Leptin Resistance” Another Key Resistance to Manage Type 2 Diabetes?
    Juan José Salazar, Mervin Chávez-Castillo, Joselyn Rojas, Ángel Ortega, Manuel Nava, José L. Pérez, Milagros Rojas, Cristóbal Ignacio Espinoza Díaz, Maricarmen Chacín, Yaneth Herazo et al. · 2019 · Current Diabetes Reviews
  5. Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease
    Mark D. Ihrie, Victoria L. McQuade, Jack T. Womble, Akhil Hegde, Matthew S. McCravy, C.V.G. Lacuesta, Robert M. Tighe, Loretta G. Que, Julia K. L. Walker, Jennifer L. Ingram · 2022 · Respiratory Research
  6. Hypothalamic Leptin and Ghrelin Signaling as Targets for Improvement in Metabolic Control
    Laura M. Frago, Julie Ann Chowen · 2015 · Current Pharmaceutical Design
  7. Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity
    Silvia Barja-Fernández, Cintia Folgueira, Cecilia Castelao, Rosaura Leis, Felipe F. Casanueva, Luisa Maria Seoane · 2015 · Gastroenterology Research and Practice
  8. Treatment of Diabetes and Obesity by Rationally Designed Peptide Agonists Functioning at Multiple Metabolic Receptors
    Noushafarin Khajavi, Heike Biebermann, Matthias H. Tschöp, Richard D. DiMarchi · 2017 · Endocrine development
  9. Adipokines and their Involvement as a Target of New Drugs
    Tania Di Raimo · 2015 · Journal of Pharmacovigilance
  10. Oleoylethanolamide modulates glucagon-like peptide-1 receptor agonist signaling and enhances exendin-4-mediated weight loss in obese mice
    Jacob D. Brown, Danielle McAnally, Jennifer E. Ayala, Melissa A. Burmeister, Camilo J. Morfa, Layton Harris Smith, Julio E. Ayala · 2018 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  11. Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet
    Takeru Sakai, Toru Kusakabe, Ken Ebihara, Daisuke Aotani, Sachiko Yamamoto‐Kataoka, Mingming Zhao, Valentino Gumbilai, Chihiro Ebihara, Megumi Aizawa‐Abe, Yuji Yamamoto et al. · 2014 · American Journal of Physiology-Endocrinology and Metabolism
  12. Gut hormones such as amylin and GLP-1 in the control of eating and energy expenditure
    Thomas A. Lutz · 2016 · International Journal of Obesity Supplements
  13. Correlation of Leptin in Patients With Type 2 Diabetes Mellitus
    Kajol Manglani, Nabila Nowshin Anika, Dhriti Patel, Sharan Jhaveri, Chaithanya Avanthika, Sourav Sudan, Zainab Alimohamed, Kripa Tiwari · 2024 · Cureus
  14. Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice
    Cintia Folgueira, Daniel Beiroa, María J. Gonzalez-Rellan, Begoña Porteiro, Edward Milbank, Cecilia Castelao, María García-Palacios, Felipe F. Casanueva, Miguel López, Carlos Diéguez et al. · 2019 · Nutrients
  15. The evolving landscape of obesity pharmacotherapy
    Jonas Petersen, Brian Finan, Valdemar Brimnes Ingemann Johansen, Timo D. Müller, Christoffer Clemmensen · 2026 · Nature Reviews Drug Discovery
  16. The brain leptin signaling system and its functional state in metabolic syndrome and type 2 diabetes mellitus
    Alexander Olegovich Shpakov · 2016 · Journal of Evolutionary Biochemistry and Physiology
  17. FGF21 Analogues and MASLD: A Summary of Preclinical and Clinical Data
    Chrysoula Boutari, Achilleas Triantafyllou, Lavrentis Papalavrentios, Ioannis Goulis, Emmanouil Sinakos · 2025 · Current Pharmaceutical Design
  18. Leptin
    Giuseppe Matarese, Claudio Procaccini, Valentina Pucino, Mantozoros Christos · 2014 · Springer eBooks
  19. Gut Peptide Agonism in the Treatment of Obesity and Diabetes
    Gerald Grandl, Aaron Novikoff, Richard D. DiMarchi, Matthias H. Tschöp, Timo D. Müller · 2019 · Comprehensive physiology
  20. A review: Anti-obesity drug discovery from natural plant metabolites and endogenous peptides
    Xiaomu Zhu, Dongdong Wang, Atanas G. Atanasov · 2024 · Current Research in Biotechnology
  21. Atomistic mechanism of leptin and leptin-receptor association
    Marisol López‐Hidalgo, Luis Alberto Caro-Gómez, Rubí Romo‐Rodríguez, Leonardo David Herrera-Zúñiga, Maricruz Anaya-Reyes, Jorge L. Rosas‐Trigueros, Claudia G. Benítez‐Cardoza · 2022 · Journal of Biomolecular Structure and Dynamics
  22. Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice
    Shantel Olivares, Anne S. Henkel · 2017 · Molecular Metabolism
  23. Improved leptin sensitivity and increased soluble leptin receptor concentrations may underlie the additive effects of combining PYY(3–36) and exendin-4 on body weight lowering in diet-induced obese mice
    Birgitte Schjellerup Wulff, Rune E. Kuhre, Madhan Selvaraj, Jens Frederik Rehfeld, Kristoffer Niss, Johannes Josef Fels, Anna Secher, Kirsten Raun, Marina Kjærgaard Gerstenberg · 2024 · Heliyon
  24. Adipokines and Metabolism
    Rexford S. Ahima, Laura M. Scolaro, Hyeong-Kyu Park · 2016 · Springer eBooks
  25. A dietary intervention following incretin analog treatment restores adipose tissue functions in diet-induced obese mice
    Joke Seuntjens, Jente De Gols, Bethan K. Davies, Fien Van Looy, Ingrid Stockmans, Karen Moermans, Geert Carmeliet, Christophe Matthys, Roman Vangoitsenhoven, Bart Van der Schueren et al. · 2025 · American Journal of Physiology-Endocrinology and Metabolism
  26. Rational Design of Dual Agonist-Antibody Fusions as Long-acting Therapeutic Hormones
    Yan Liu, Ying Wang, Yong Zhang, Tao Liu, Haiqun Jia, Huafei Zou, Qiangwei Fu, Yuhan Zhang, Lucy Lu, Elizabeth Chao et al. · 2016 · ACS Chemical Biology
  27. Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity
    Xun Sun, Lincoln Brueck, Dongming Yang, Patrick L. Sheets, Baohua Zhou, Hongxia Ren · 2025 · Journal of Biological Chemistry
  28. From leptin to lasers: the past and present of mouse models of obesity
    Joshua R. Barton, Adam Eugene Snook, Scott Arthur Waldman · 2021 · Expert Opinion on Drug Discovery
  29. Examining the Potential Applicability of Orexigenic and Anorexigenic Peptides in Veterinary Medicine for the Management of Obesity in Companion Animals
    Cezary Osiak-Wicha, Katarzyna Kras, Ewa Tomaszewska, Siemowit Muszyński, Marcin Bartłomiej Arciszewski · 2024 · Current Issues in Molecular Biology
  30. Pharmacological administration of FGF21 reverses obesity through a parabrachial-projecting neuron population in the hindbrain
    Yunfan Lin, Kristin E. Claflin, İltan Aklan, Donald A. Morgan, Andrew I. Sullivan, Michael C. Rudolph, Kamal Rahmouni, Matthew J. Potthoff · 2026 · Cell Reports
  31. Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases
    Richard D. DiMarchi, John P. Mayer, Vasily M. Gelfanov, Matthias H. Tschöp · 2018 · Journal of Peptide Science
  32. Adipokines and Metabolism
    Rexford S. Ahima, Laura M. Scolaro, Hyeong-Kyu Park · 2015 · Springer eBooks
  33. Potential Leptin Receptor Response Modifier Peptides
    Laszlo Jr Otvos · 2019 · Australian Journal of Chemistry
  34. Evaluation of leptin treatment on maintenance of body weight loss in diet‐induced obese mice
    Danna M. Breen, Rocío del M. Saavedra-Peña, Stephanie Joaquim, Jimmy Kong, Ryan Reese, J. Brent Kuzmiski, John C. Stansfield, Rhys Jones, Kendra K. Bence, V. Margaret Jackson · 2025 · Diabetes Obesity and Metabolism
  35. The Future of Diabetes
    Zachary T. Bloomgarden · 2015 · Canadian Journal of Diabetes
  36. Novel Combinatorial Therapies Involving Leptin: Opportunities for Mechanistic Advances and Therapeutic Translation in Human Diseases
    Timo D. Müller, Christoffer Clemmensen, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp · 2014 · Springer eBooks
  37. Critically Discuss the Revival of Leptin for Obesity Therapy
    Chi-Fai Lo · 2018 · Psychology
  38. Aproximaciones farmacológicas para el tratamiento de la obesidad
    Milton Enrique Londoño-Lemos · 2017 · Revista Colombiana de Ciencias Químico Farmacéuticas
  39. Adipokines and Metabolism
    Rexford S. Ahima, Hyeong Kyu Park · 2023 · Springer eBooks
  40. The potential of glucagon-like peptide 1 to reverse high-fat, high-sugar diet-related metabolic damage
    Timo D. Müller · 2014 · Expert Review of Endocrinology & Metabolism
  41. Untersuchung des Einflusses von Leptin auf die Thrombozytenfunktion sowie Analyse der Leptin-vermittelten Signalkaskade in Thrombozyten
    Ilonka Rohm · 2015
  42. Gut-Brain Communication in the Regulation of System Metabolism
    Timo D. Müller, Paul T. Pfluger, Matthias H. Tschöp · 2013 · Else Kröner-Fresenius Symposia
  43. Disparate bedfellows in a lasting drug union?
    Evan R. Simpson, Peter J. Fuller · 2013 · Nature Reviews Endocrinology
  44. The metabolic effects of leptin therapy and glucagon suppression therapy in mouse models of diabetes
    Neumann, Ursula Hope · 2017 · cIRcle (University of British Columbia)
  45. Drug Treatment of Obesity: From Bench to Bedside
    Jelena Jakab, Robert Smolić, Aleksandar Včev, Martina Smolić · 2018 · InTech eBooks
  46. Endocrine Mechanisms in Obesity
    Katrin Fischer, Timo D. Müller · 2018 · Elsevier eBooks
  47. Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the FGF21 locus
    Ali Bayoumi · 2020 · The Sydney eScholarship Repository (The University of Sydney)
  48. The Future of Diabetes
    Mariela Glandt, Zachary T. Bloomgarden · 2016 · Springer eBooks
  49. The Future of Diabetes
    Mariela Glandt, Zachary T. Bloomgarden · 2017 · Springer eBooks
  50. Ätiologie
    Susann Blüher, Mattias Blüher, W. Kiess, Anke Hinney, Ina Nehring, R. von Kries, Regina E. Ensenauer, Wolfgang Langhans, Sonja Charlotte Schriever, Chun‐Xia Yi et al. · 2013 · Springer eBooks
  51. Adipokines and Metabolism
    Rexford S. Ahima, Laura M. Scolaro, Hyeong-Kyu Park · 2017 · Springer eBooks
  52. Adipokines and Metabolism
    Rexford S. Ahima, Hyeong Kyu Park · 2023 · Springer eBooks
  53. Gastrointestinale Regulation des Energiestoffwechsels
    Sonja Charlotte Schriever, Chun‐Xia Yi, Paul T. Pfluger, Matthias H. Tschöp, Timo D. Müller · 2024 · Springer eBooks
  54. Gut Peptide Agonism in the Treatment of Obesity and Diabetes
    Gerald Grandl, Aaron Novikoff, Richard D. DiMarchi, Matthias H. Tschoep, Timo D. Müller · 2020 · Comprehensive physiology
  55. Additional file 1 of Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease
    Mark D. Ihrie, Victoria L. McQuade, Jack T. Womble, Akhil Hegde, Matthew S. McCravy, C.V.G. Lacuesta, Robert M. Tighe, Que, Loretta G., Julia K. L. Walker, Ingram, Jennifer L. · 2022 · Figshare
  56. Can Leptin Responsiveness Be Restored in Common Human Obesity?
    J. A. M. J. L. Janssen · 2026 · Lipidology
  57. Canonical and Non-Canonical Regulators of Lipid Metabolism in the Liver and the “Liver–Other Organs” Axes
    Stanislav Nikolaevich Kotlyarov, Анна Анатольевна Котлярова, Roberto Catanzaro, Francesco Marotta · 2026 · International Journal of Molecular Sciences