A Philosophical Framework for Integrating Systems Pharmacology Models Into Pharmacometrics
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The framework for systems pharmacology style models does not naturally sit with the usual scientific dogma of parsimony and falsifiability based on deductive reasoning. This does not invalidate the importance or need for overarching models based on pharmacology to describe and understand complicated biological systems. However, it does require some consideration on how systems pharmacology fits into the overall scientific approach.
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Techniques exist to establish model parameter redundancy, which alongside structural identifiability analysis can support model reparameterization or lumping if required.
“In addition, there are also techniques available in the literature60, 61 to establish model parameter redundancy, which alongside structural identifiability analysis can support model reparameterization or lumping, should this be required.62”
From Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network (2019) · cites this paper as [62]
In Example 2 (page unavailable), Duffull describes an unidentifiable coagulation model that was reduced from 73 to 5 differential equations using proper lumping. The paper thus supports lumping in response to identifiability problems, but does not describe reparameterization or establish that structural identifiability analysis and parameter-redundancy techniques jointly support those steps. (LLM, conf=0.83)
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References 25 · Cited by 3
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- Authors
- Duffull, S.
- Affiliations
- Otago Pharmacometrics Group, School of Pharmacy, University of Otago Dunedin New Zealand
- Venue
- CPT: Pharmacometrics & Systems Pharmacology
- Publisher
- Wiley
- Published
- 2016-11-12
- Volume
- 5
- Issue
- 12
- Pages
- 649-655
- ISSN
- 2163-8306 (ISSN-L)
- PMC
- PMC5192992
- OpenAlex
- W2554930269
- Cited by
- 3
- References
- 25
- Citations by year
- 2022: 1 · 2019: 1 · 2018: 1
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- CPT Pharmacometrics & Systems Pharmacology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- systems pharmacology, pharmacometrics, model integration, falsifiability, deductive reasoning, mathematical biology, philosophy of science
- MeSH terms
- Computer Simulation, Humans, Models, Theoretical, Pharmacology, Clinical, Systems Analysis, Systems Integration, Systems Biology
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