The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The protective effect of Allium sativum L. clove aqueous and methanolic extracts against hypoxia‐induced lethality in mice
Open accessAbstract
The antihypoxic activity of Allium sativum clove (garlic) aqueous and methanolic extracts was studied in mice. The extracts of garlic showed that the antihypoxic effect was dose‐dependent. The minimum effective doses of aqueous and methanolic extracts were 0.2 g/kg and 5.12 g/kg, respectively. Phenytoin, 50 mg/kg, and R‐phenylisopropyladenosine (R‐PIA), 1.6 mg/kg (R‐PIA) as positive controls increased survival time up to 52.5 ± 2.9 min and 120.5 ± 6 min, respectively, compared to normal saline (34.73 ± 0.71 min). The high doses of aqueous (16.9 g/kg) and methanolic (12.8 g/kg) extracts increased survival time up to 73.17 ± 4.9 and 68.41 ± 3.7, respectively. These results indicated that the extracts of A. sativum cloves have a protective effect against hypoxia‐induced lethality in mice. Copyright © 2003 John Wiley & Sons, Ltd.
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“Allium spp. on the other hand, has been widely utilized not only as spices for food but also for treatment against wide range of microorganisms including fungi11–17.”
From Bioactivities of Allium longicuspis Regel against anthracnose of mango caused by Colletotrichum gloeosporioides (Penz.) (2020) · cites this paper as [12]
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Cites
In Vitro Virucidal Effects of Allium sativum(Garlic) Extract and Compounds
Weber, N., Andersen, D., North, J., Murray, B., Lawson, L., & Hughes, B. (1992) · Planta Medica · doi:10.1055/s-2006-961504 · Cited by 327
Lawson, L. D., Ransom, D. K., & Hughes, B. G. (1992) · Thrombosis Research · doi:10.1016/0049-3848(92)90234-2 · Cited by 271
Bordia, A., Verma, S. K., & Srivastava, K. C. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90034-5 · Cited by 249
Garlic and onions: their effect on eicosanoid metabolism and its clinical relevance
Ali, M., Thomson, M., & Afzal, M. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.1999.0124 · Cited by 201
Ali, M., Al‐Qattan, K. K., Alenezi, F., Khanafer, R. M. A., & Mustafa, T. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0152 · Cited by 188
The antiatherosclerotic effect of Allium sativum
Koscielny, J. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00060-x · Cited by 165
Helicobacter pylori—in vitrosusceptibility to garlic(Allium sativum)extract
Sivam, G. P., Lampe, J. W., Ulness, B. K., Swanzy, S. R., & Potter, J. D. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514512 · Cited by 150
Al‐Qattan, K. K., Alnaqeeb, M. A., & Ali, M. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00173-1 · Cited by 74
THE POTENTIAL APPLICATION OF ALLIUM SATIVUM (GARLIC) FOR THE TREATMENT OF BLADDER CANCER
Lamm, D. L., & Riggs, D. R. (2000) · Urologic Clinics of North America · doi:10.1016/s0094-0143(05)70243-3 · Cited by 71
Pasini, F. L., Guideri, F., Picano, E., et al. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00240-3 · Cited by 64
Research works printed but not linked: 2
- Melzig MF, 1995, Franke S Inhibition of adenosine deaminase activity of aortic endothelial cells by extracts of garlic (Allium sativum L.), Pharmazie, 50, 359
- O'Gara EA, 2000, Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori Appl Environ, Microbiol, 66, 2269
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de Guzman Alvindia, D., & Mangoba, M. A. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68399-z · Cited by 18
Mangoba, M. A. A., & Alvindia, D. D. G. (2019) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2019.1702898 · Cited by 8
Metadata
- Authors
- Hosseinzadeh, H., & Sadati, N.
- Affiliations
- Mashhad University of Medical Sciences (IR)
- Corresponding author
- Hosseinzadeh, Hossein
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2003-03
- Volume
- 17
- Issue
- 3
- Pages
- 279-281
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2052186636
- Cited by
- 13
- References
- 16
- Citations by year
- 2025: 2 · 2023: 1 · 2020: 2 · 2019: 1 · 2015: 1 · 2014: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mashhad University of Medical Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Saffron Plant Research Studies
- Keywords
- garlic, clove extract, hypoxia, antihypoxic activity, survival time, aqueous extract, methanol extract, phenytoin, R-PIA
- MeSH terms
- Animals, Hypoxia, Brain, Dose-Response Relationship, Drug, Female, Garlic, Injections, Intraperitoneal, Male, Phytotherapy, Phenylisopropyladenosine, Phenytoin, Plant Extracts, Neuroprotective Agents, Mice
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