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Antiplasmodial constituents of Cajanus cajan
Abstract
Bioactivity-guided fractionation of extracts of roots and leaves of Cajanus cajan afforded 8 compounds: betulinic acid, biochanin A, cajanol, genistein and 2'-hydroxygenistein, longistylin A and C, and pinostrobin. The two stilbenes, longistylin A and C, and betulinic acid showed a moderately high in vitro activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7.
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Extracts of Cajanus cajan leaves show therapeutic effects on sickle cell anaemia, plasmodiosis, and diabetes.
“The extracts of C. cajan leaves show therapeutic effects on sickle cell anaemia, plasmodiosis, and diabetes [15-17].”
Phenolics, including flavonoids and stilbenes, are the major active components in Cajanus cajan leaves.
“Chemical and pharmacological investigations revealed that phenolics (flavonoids and stilbenes) were the major active components in C. cajan leaves [16,18,19].”
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- ZieglerH Franzyk H SairafianpourM TabatabaiM TehraniMD BagherzadehK HägerstrandH StærkD JaroszewskiJW.2003. Erythrocyte membrane modifications and the inhibition ofPlasmodium falciparum growth:structure‐activity relationships for betulinic acid analogues.Bioorg. Med. Chem. In press.
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Wei, Z., Qi, X., Li, T., Luo, M., Wang, W., Zu, Y., & Fu, Y. (2015) · Separation and Purification Technology · doi:10.1016/j.seppur.2015.05.015 · Cited by 274
Metadata
- Authors
- Duker‐Eshun, G., Jaroszewski, J. W., Asomaning, W. A., Oppong‐Boachie, F., & Brøgger Christensen, S.
- Affiliations
- University of Ghana (GH)
- Centre for Plant Medicine Research (GH)
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2004-02
- Volume
- 18
- Issue
- 2
- Pages
- 128-130
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2058365223
- Cited by
- 131
- References
- 0
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 10 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 10 · 2013: 9 · 2012: 13
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Danish International Development Agency
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and bioactivity of alkaloids
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Keywords
- Cajanus cajan, Vigna mungo, antimalarial activity, Plasmodium falciparum, betulinic acid, biochanin A, genistein, pinostrobin, stilbenes, bioassay-guided fractionation, roots and leaves, chloroquine-sensitive strain
- MeSH terms
- Animals, Antimalarials, Humans, Phytotherapy, Plant Extracts, Plasmodium falciparum, Malaria, Falciparum, Plant Leaves, Plant Roots, Parasitic Sensitivity Tests, Cajanus
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