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Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea
Abstract
(−)‐Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of extracts of green tea. EGCG slightly inhibited specific binding of [3 H] 12‐0‐tetradecanoylphorbol‐13‐acetate ([3 H]TPA) to a particulate fraction of mouse skin, and caused a prompt decrease in the phorbol ester receptor number in mouse skin. It also inhibited the activation of protein kinase C by teleocidin. In week 25 of a two‐stage carcinogenesis experiment in mouse skin, tumors were found in 53% of the mice treated with 7,12‐dimethylbenz(a)anthracene (DMBA) plus teleocidin, but in only 13% of those treated with DMBA plus teleocidin and EGCG. The average number of tumors per mouse in these groups was 2.1 and 0.1, respectively. No tumors were found in other groups treated with DMBA alone or teleocidin and EGCG alone. Thus EGCG inhibited tumor promotion by teleocidin.
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Cited by
Tannins and Human Health: A Review
Chung, K.-T., Wong, T. Y., Wei, C.-I., Huang, Y.-W., & Lin, Y. (1998) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408699891274273 · Cited by 1,996
Quantification of genistein and genistin in soybeans and soybean products
Fukutake, M., Takahashi, M., Ishida, K., Kawamura, H., Sugimura, T., & Wakabayashi, K. (1996) · Food and Chemical Toxicology · doi:10.1016/0278-6915(96)87355-8 · Cited by 296
Self-citationDNA and RNA as New Binding Targets of Green Tea Catechins
Kuzuhara, T., Sei, Y., Yamaguchi, K., Suganuma, M., & Fujiki, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601196200 · Cited by 151
Self-citationGensler, H. L., Timmermann, B. N., Valcic, S., Wächter, G. A., Dorr, R., Dvorakova, K., & Alberts, D. S. (1996) · Nutrition and Cancer · doi:10.1080/01635589609514488 · Cited by 133
Dvorakova, K., Dorr, R. T., Valcic, S., Timmermann, B., & Alberts, D. S. (1999) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800050903 · Cited by 96
Metadata
- Authors
- Yoshizawa, S., Horiuchi, T., Fujiki, H., Yoshida, T., Okuda, T., & Sugimura, T.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 1987-03
- Volume
- 1
- Issue
- 1
- Pages
- 44-47
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W1987841769
- Cited by
- 290
- References
- 0
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yoshizawa, S., Horiuchi, T., Fujiki, H., Yoshida, T., Okuda, T., & Sugimura, T. (1987). Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea. Phytotherapy Research. https://doi.org/10.1002/ptr.2650010110
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