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Natural products: A lead for drug discovery and development

Chopra, Bhawna, Dhingra, Ashwani Kumar·2021·Phytotherapy Research

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Abstract

Natural products are used since ancient times in folklore for the treatment of various ailments. Plant‐derived products have been recognized for many years as a source of therapeutic agents and structural diversity. A literature survey has been carried out to determine the utility of natural molecules and their modified analogs or derivatives as pharmacological active entities. This review presents a study on the importance of natural products in terms of drug discovery and development. It describes how the natural components can be utilized after small modifications in new perspectives. Various new modifications in structure offer a unique opportunity to establish a new molecular entity with better pharmacological potential. It was concluded that in this current era, new attempts are taken to utilize the compounds derived from natural sources as novel drug candidates, with a focus to find and discover new effective molecules that were referred to as “new entities of natural product drug discovery.”

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Self-citation

Authors: Chopra, B., & Dhingra, A. K.
Venue: Phytotherapy Research
Publisher: Wiley
Published: 2021-04-13
Volume: 35
Issue: 9
Pages: 4660-4702
ISSN: 0951-418X (ISSN-L)
1099-1573
DOI: 10.1002/ptr.7099
OpenAlex: W3156782050
Cited by: 469
References: 254
FWCI: 14.42
Type: journal article
Language: en
Open access: closed

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Natural products: A lead for drug discovery and development

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