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Cinnamic acid derivatives as matrices for ultraviolet laser desorption mass spectrometry of proteins
Abstract
The paper reports the discovery of three new matrices for the matrix‐assisted laser desorption of proteins. These new matrices (sinapic, ferulic and caffeic acids) are cinnamic acid derivatives that have several pratical advantages over the nicotinic acid matrices previously used. These materials form much less intense photochemically generated adduct peaks in the protein quasimolecular ion signal and the adduct peaks that are present are easier to resolve. These new matrices are produce intense protonated‐molecule ions from all of the proteins (over 50) so far examined. These new matrices are also very stable in a vacuum, allowing for their convenient use in very high vacuum applications (e.g., Fourier transform ion cyclotron resonance mass spectrometry).
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Citations
Cited by
Rapid, sensitive analysis of protein mixtures by mass spectrometry.
Beavis, R. C., & Chait, B. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6873 · Cited by 301
Self-citationMethods for samples preparation in proteomic research
Bodzon-Kulakowska, A., Bierczynska-Krzysik, A., Dylag, T., Drabik, A., Suder, P., Noga, M., Jarzebinska, J., & Silberring, J. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.10.040 · Cited by 254
Metadata
- Authors
- Beavis, R. C., Chait, B. T., & Fales, H. M.
- Venue
- Rapid Communications in Mass Spectrometry
- Publisher
- Wiley
- Published
- 1989-12
- Volume
- 3
- Issue
- 12
- Pages
- 432-435
- ISSN
- 0951-4198 (ISSN-L)
- 1097-0231
- OpenAlex
- W2131593670
- Cited by
- 416
- References
- 0
- FWCI
- 19.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cinnamic acid derivatives as matrices for ultraviolet laser desorption mass spectrometry of proteins. https://app.cochat.ai/papers/10.1002/rcm.1290031207
- The paper
- Beavis, R. C., Chait, B. T., & Fales, H. M. (1989). Cinnamic acid derivatives as matrices for ultraviolet laser desorption mass spectrometry of proteins. Rapid Communications in Mass Spectrometry. https://doi.org/10.1002/rcm.1290031207
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
