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Enhancements in travelling wave ion mobility resolution
Abstract
The use of ion mobility separation to determine the collision cross‐section of a gas‐phase ion can provide valuable structural information. The introduction of travelling‐wave ion mobility within a quadrupole/time‐of‐flight mass spectrometer has afforded routine collision cross‐section measurements to be performed on a range of ionic species differing in gas‐phase size/structure and molecular weight at physiologically relevant concentrations. Herein we discuss the technical advances in the second‐generation travelling‐wave ion mobility separator, which result in up to a four‐fold increase in mobility resolution. This improvement is demonstrated using two reverse peptides (mw 490 Da), small ruthenium‐containing anticancer drugs (mw 427 Da), a cisplatin‐modified protein (mw 8776 Da) and the noncovalent tetradecameric chaperone complex GroEL (mw 802 kDa). What is also shown are that the collision cross‐sections determined using the second‐generation mobility separator correlate well with the previous generation and theoretically derived values. Copyright © 2011 John Wiley & Sons, Ltd.
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Cited by
Lanucara, F., Holman, S. W., Gray, C. J., & Eyers, C. E. (2014) · Nature Chemistry · doi:10.1038/nchem.1889 · Cited by 901
Ion Mobility Spectrometry: Fundamental Concepts, Instrumentation, Applications, and the Road Ahead
Dodds, J. N., & Baker, E. S. (2019) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-019-02288-2 · Cited by 574
Leung, Y. H., Ng, A. M. C., Xu, X., Shen, Z., Gethings, L. A., Wong, M. T., Chan, C. M. N., Guo, M. Y., Ng, Y. H., Djurišić, A. B., et al. (2014) · Small · doi:10.1002/smll.201302434 · Cited by 566
Recommendations for reporting ion mobility Mass Spectrometry measurements
Gabelica, V., Shvartsburg, A. A., Afonso, C., Barran, P., Benesch, J. L. P., Bleiholder, C., Bowers, M. T., Bilbao, A., Bush, M. F., Campbell, J. L., et al. (2019) · Mass Spectrometry Reviews · doi:10.1002/mas.21585 · Cited by 493
Self-citationLapthorn, C., Pullen, F., & Chowdhry, B. Z. (2013) · Mass Spectrometry Reviews · doi:10.1002/mas.21349 · Cited by 398
Metadata
- Authors
- Giles, K., Williams, J. P., & Campuzano, I.
- Venue
- Rapid Communications in Mass Spectrometry
- Publisher
- Wiley
- Published
- 2011-05-11
- Volume
- 25
- Issue
- 11
- Pages
- 1559-1566
- ISSN
- 0951-4198 (ISSN-L)
- 1097-0231
- OpenAlex
- W2115588498
- Cited by
- 369
- References
- 0
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- closed
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