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Cited by 434

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Fixed effects, random effects and GEE: What are the differences?

Gardiner, Joseph C., Luo, Zhehui, Roman, Lee Anne·2009·Statistics in Medicine

Abstract

For analyses of longitudinal repeated‐measures data, statistical methods include the random effects model, fixed effects model and the method of generalized estimating equations. We examine the assumptions that underlie these approaches to assessing covariate effects on the mean of a continuous, dichotomous or count outcome. Access to statistical software to implement these models has led to widespread application in numerous disciplines. However, careful consideration should be paid to their critical assumptions to ascertain which model might be appropriate in a given setting. To illustrate similarities and differences that might exist in empirical results, we use a study that assessed depressive symptoms in low‐income pregnant women using a structured instrument with up to five assessments that spanned the pre‐natal and post‐natal periods. Understanding the conceptual differences between the methods is important in their proper application even though empirically they might not differ substantively. The choice of model in specific applications would depend on the relevant questions being addressed, which in turn informs the type of design and data collection that would be relevant. Copyright © 2008 John Wiley & Sons, Ltd.

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Metadata

Authors
Gardiner, J. C., Luo, Z., & Roman, L. A.
Venue
Statistics in Medicine
Publisher
Wiley
Published
2008-11-14
Volume
28
Issue
2
Pages
221-239
ISSN
  • 0277-6715 (ISSN-L)
  • 1097-0258
OpenAlex
W2003750542
Cited by
434
References
63
FWCI
7.14
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Fixed effects, random effects and GEE: What are the differences? https://app.cochat.ai/papers/10.1002/sim.3478
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Gardiner, J. C., Luo, Z., & Roman, L. A. (2009). Fixed effects, random effects and GEE: What are the differences? Statistics in Medicine. https://doi.org/10.1002/sim.3478

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