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Cited by 243

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A Bayesian semiparametric multivariate joint model for multiple longitudinal outcomes and a time‐to‐event

Rizopoulos, Dimitris, Ghosh, Pulak·2011·Statistics in Medicine

Abstract

Motivated by a real data example on renal graft failure, we propose a new semiparametric multivariate joint model that relates multiple longitudinal outcomes to a time‐to‐event. To allow for greater flexibility, key components of the model are modelled nonparametrically. In particular, for the subject‐specific longitudinal evolutions we use a spline‐based approach, the baseline risk function is assumed piecewise constant, and the distribution of the latent terms is modelled using a Dirichlet Process prior formulation. Additionally, we discuss the choice of a suitable parameterization, from a practitioner's point of view, to relate the longitudinal process to the survival outcome. Specifically, we present three main families of parameterizations, discuss their features, and present tools to choose between them. Copyright © 2011 John Wiley & Sons, Ltd.

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Metadata

Authors
Rizopoulos, D., & Ghosh, P.
Venue
Statistics in Medicine
Publisher
Wiley
Published
2011-02-21
Volume
30
Issue
12
Pages
1366-1380
ISSN
  • 0277-6715 (ISSN-L)
  • 1097-0258
OpenAlex
W2030840862
Cited by
243
References
1
FWCI
9.74
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Bayesian semiparametric multivariate joint model for multiple longitudinal outcomes and a time‐to‐event. https://app.cochat.ai/papers/10.1002/sim.4205
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Rizopoulos, D., & Ghosh, P. (2011). A Bayesian semiparametric multivariate joint model for multiple longitudinal outcomes and a time‐to‐event. Statistics in Medicine. https://doi.org/10.1002/sim.4205

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