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Constructing time‐specific reference ranges
Abstract
Reference ranges which take time (such as age) into account are often required in medicine, but simple, systematic and efficient statistical methods for constructing them are lacking. A method is described which is based on low order polynomial curves (linear, quadratic or occasionally cubic), together with guidelines for when and how to apply a logarithmic transformation to the variable analysed, testing for departures from normality, and assessment of the adequacy of the reference range which is constructed from the regression line plus or minus a multiple of the standard deviation. Standard statistical packages may be used to carry out the calculations. The question of comparing two or more groups of patients is addressed. Three examples are discussed in detail.
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Cited by
Trajectories of growth among children who have coronary events as adults
Barker, D. J. P., Osmond, C., Forsén, T. J., Kajantie, E., & Eriksson, J. G. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044160 · Cited by 1,517
Bhargava, S. K., Sachdev, H. S., Fall, C. H. D., Osmond, C., Lakshmy, R., Barker, D. J. P., Biswas, S. K. D., Ramji, S., Prabhakaran, D., & Reddy, K. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035698 · Cited by 1,037
Early growth and coronary heart disease in later life: longitudinal study
Eriksson, J. G., Forsén, T., Tuomilehto, J., Osmond, C., & Barker, D. J. P. (2001) · BMJ · doi:10.1136/bmj.322.7292.949 · Cited by 1,016
Papageorghiou, A. T., Ohuma, E. O., Altman, D. G., Todros, T., Ismail, L. C., Lambert, A., Jaffer, Y. A., Bertino, E., Gravett, M. G., Purwar, M., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61490-2 · Cited by 870
The Fetal and Childhood Growth of Persons Who Develop Type 2 Diabetes
Forsén, T., Eriksson, J., Tuomilehto, J., Reunanen, A., Osmond, C., & Barker, D. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-3-200008010-00008 · Cited by 721
Metadata
- Authors
- Royston, P.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 1991-05
- Volume
- 10
- Issue
- 5
- Pages
- 675-690
- ISSN
- 0277-6715 (ISSN-L)
- 1097-0258
- OpenAlex
- W2171888399
- Cited by
- 310
- References
- 0
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Royston, P. (1991). Constructing time‐specific reference ranges. Statistics in Medicine. https://doi.org/10.1002/sim.4780100502
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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