The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Statistical handling of drop‐outs in longitudinal clinical trials
Abstract
This paper considers the statistical complexities that arise due to outcome related drop‐outs in longitudinal clinical trials of the randomized parallel groups design with fixed assessment times and an explanatory aim. The shortcomings of currently popular methods of coping with the problem of drop‐outs are discussed. It is proposed that progress can be made by applying the modern methodology that was primarily developed for sample surveys with non‐response and for observational studies. A practical application using the Hamilton Rating Scale for Depression is presented.
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Citations
Cites
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701
A REVIEW OF GOODNESS OF FIT STATISTICS FOR USE IN THE DEVELOPMENT OF LOGISTIC REGRESSION MODELS1
LEMESHOW, S., & HOSMER, D. W. (1982) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113284 · Cited by 1,947
Cited by
Modeling the Drop-Out Mechanism in Repeated-Measures Studies
Little, R. J. A. (1995) · Journal of the American Statistical Association · doi:10.1080/01621459.1995.10476615 · Cited by 1,522
Resick, P. A., Nishith, P., Weaver, T. L., Astin, M. C., & Feuer, C. A. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.4.867 · Cited by 1,294
Application of random-effects pattern-mixture models for missing data in longitudinal studies.
Hedeker, D., & Gibbons, R. D. (1997) · Psychological Methods · doi:10.1037/1082-989x.2.1.64 · Cited by 907
Statistical Considerations in the Intent-to-Treat Principle
Lachin, J. M. (2000) · Controlled Clinical Trials · doi:10.1016/s0197-2456(00)00046-5 · Cited by 652
ACCOUNTING FOR DROPOUT BIAS USING MIXED-EFFECTS MODELS
Mallinckrodt, C. H., Clark, W. S., & David, S. R. (2001) · Journal of Biopharmaceutical Statistics · doi:10.1081/bip-100104194 · Cited by 398
Metadata
- Authors
- Heyting, A., Tolboom, J. T. B. M., & Essers, J. G. A.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 1992-01
- Volume
- 11
- Issue
- 16
- Pages
- 2043-2061
- ISSN
- 0277-6715 (ISSN-L)
- 1097-0258
- OpenAlex
- W2164636269
- Cited by
- 238
- References
- 2
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Statistical handling of drop‐outs in longitudinal clinical trials. https://app.cochat.ai/papers/10.1002/sim.4780111603
- The paper
- Heyting, A., Tolboom, J. T. B. M., & Essers, J. G. A. (1992). Statistical handling of drop‐outs in longitudinal clinical trials. Statistics in Medicine. https://doi.org/10.1002/sim.4780111603
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
