The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Multiple hypothesis testing in genomics
Abstract
This paper presents an overview of the current state of the art in multiple testing in genomics data from a user's perspective. We describe methods for familywise error control, false discovery rate control and false discovery proportion estimation and confidence, both conceptually and practically, and explain when to use which type of error rate. We elaborate on the assumptions underlying the methods and discuss pitfalls in the interpretation of results. In our discussion, we take into account the exploratory nature of genomics experiments, looking at selection of genes before or after testing, and at the role of validation experiments.
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
A Simple Sequentially Rejective Multiple Test Procedure
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In silico prediction of protein-protein interactions in human macrophages
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Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Why Most Published Research Findings Are False
Ioannidis, J. P. A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020124 · Cited by 10,505
The control of the false discovery rate in multiple testing under dependency
Benjamini, Y., & Yekutieli, D. (2001) · The Annals of Statistics · doi:10.1214/aos/1013699998 · Cited by 10,490
A Gene-Expression Signature as a Predictor of Survival in Breast Cancer
van de Vijver, M. J., He, Y. D., van 't Veer, L. J., Dai, H., Hart, A. A. M., Voskuil, D. W., Schreiber, G. J., Peterse, J. L., Roberts, C., Marton, M. J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021967 · Cited by 6,488
No adjustments are needed for multiple comparisons.
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What's wrong with Bonferroni adjustments
Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900
A Direct Approach to False Discovery Rates
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Cited by
Meta-analysis of 2,104 trios provides support for 10 new genes for intellectual disability
Lelieveld, S. H., Reijnders, M. R. F., Pfundt, R., Yntema, H. G., Kamsteeg, E.-J., de Vries, P., de Vries, B. B. A., Willemsen, M. H., Kleefstra, T., Löhner, K., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4352 · Cited by 442
A practical guide to methods controlling false discoveries in computational biology
Korthauer, K., Kimes, P. K., Duvallet, C., Reyes, A., Subramanian, A., Teng, M., Shukla, C., Alm, E. J., & Hicks, S. C. (2019) · Genome Biology · doi:10.1186/s13059-019-1716-1 · Cited by 436
Rubin, M. (2021) · Synthese · doi:10.1007/s11229-021-03276-4 · Cited by 371
Truhn, D., Schrading, S., Haarburger, C., Schneider, H., Merhof, D., & Kuhl, C. (2019) · Radiology · doi:10.1148/radiol.2018181352 · Cited by 273
When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment
Szucs, D., & Ioannidis, J. P. A. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00390 · Cited by 298
Metadata
- Authors
- Goeman, J. J., & Solari, A.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 2014-01-08
- Volume
- 33
- Issue
- 11
- Pages
- 1946-1978
- ISSN
- 0277-6715 (ISSN-L)
- OpenAlex
- W2099657218
- Cited by
- 375
- References
- 108
- FWCI
- 24.40
- Type
- journal article
- Language
- en
- Open access
- closed
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