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The Influence of Nanoparticle Shape on Protein Corona Formation
Open accessAbstract
Nanoparticles have become an important utility in many areas of medical treatment such as targeted drug and treatment delivery as well as imaging and diagnostics. These advances require a complete understanding of nanoparticles' fate once placed in the body. Upon exposure to blood, proteins adsorb onto the nanoparticles surface and form a protein corona, which determines the particles' biological fate. This study reports on the protein corona formation from blood serum and plasma on spherical and rod‐shaped nanoparticles. These two types of mesoporous silica nanoparticles have identical chemistry, porosity, surface potential, and size in the y‐dimension, one being a sphere and the other a rod shape. The results show a significantly larger amount of protein attaching from both plasma and serum on the rod‐like particles compared to the spheres. Interrogation of the protein corona by liquid chromatography–mass spectrometry reveals shape‐dependent differences in the adsorption of immunoglobulins and albumin proteins from both plasma and serum. This study points to the need for taking nanoparticle shape into consideration because it can have a significant impact on the fate and therapeutic potential of nanoparticles when placed in the body.
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The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (bbb).
Kreuter, J. (2013) · Journal of Microencapsulation · doi:10.3109/02652048.2012.692491 · Cited by 172
Cited by
Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Sousa de Almeida, M., Susnik, E., Drasler, B., Taladriz-Blanco, P., Petri-Fink, A., & Rothen-Rutishauser, B. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01127d · Cited by 1,079
Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier
Zha, S., Liu, H., Li, H., Li, H., Wong, K.-L., & All, A. H. (2024) · ACS Nano · doi:10.1021/acsnano.3c10674 · Cited by 378
The protein corona and its effects on nanoparticle-based drug delivery systems
Li, H., Wang, Y., Tang, Q., Yin, D., Tang, C., He, E., Zou, L., & Peng, Q. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.019 · Cited by 265
Unmasking CSF protein corona: Effect on targeting capacity of nanoparticles
Wang, Y., Zhang, H., Xiao, W., Liu, Y., Zhou, Y., He, X., Xia, X., Gong, T., Wang, L., & Gao, H. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.001 · Cited by 48
Metadata
- Authors
- Madathiparambil Visalakshan, R., González García, L. E., Benzigar, M. R., Ghazaryan, A., Simon, J., Mierczynska‐Vasilev, A., Michl, T. D., Vinu, A., Mailänder, V., Morsbach, S., Landfester, K., & Vasilev, K.
- Venue
- Small
- Publisher
- Wiley
- Published
- 2020-05-14
- Volume
- 16
- Issue
- 25
- Pages
- e2000285-e2000285
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W3025755290
- Cited by
- 201
- References
- 2
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Madathiparambil Visalakshan, R., González García, L. E., Benzigar, M. R., Ghazaryan, A., Simon, J., Mierczynska‐Vasilev, A., Michl, T. D., Vinu, A., Mailänder, V., Morsbach, S., Landfester, K., & Vasilev, K. (2020). The Influence of Nanoparticle Shape on Protein Corona Formation. Small. https://doi.org/10.1002/smll.202000285
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