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Cited by 81Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryMesenchymal stem cell research

Harnessing the Therapeutic Potential of Extracellular Vesicles for Biomedical Applications Using Multifunctional Magnetic Nanomaterials

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Yang, Letao, Patel, Kapil D., Rathnam, Christopher, Thangam, Ramar, Hou, Yannan, Kang, Heemin, Lee, Ki‐Bum·2022·Small
DOI 10.1002/smll.202104783PMC PMC9344859
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Abstract

Extracellular vesicles (e.g., exosomes) carrying various biomolecules (e.g., proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, their heterogeneity in surfaces and sizes, the high complexity of cargo biomolecules, and the inefficient uptake by recipient cells remain critical barriers for their theranostic applications. To address these critical issues, multifunctional nanomaterials, such as magnetic nanomaterials, with their tunable physical, chemical, and biological properties, may play crucial roles in next‐generation extracellular vesicles (EV)‐based disease diagnosis, drug delivery, tissue engineering, and regenerative medicine. As such, one aims to provide cutting‐edge knowledge pertaining to magnetic nanomaterials‐facilitated isolation, detection, and delivery of extracellular vesicles and their associated biomolecules. By engaging the fields of extracellular vesicles and magnetic nanomaterials, it is envisioned that their properties can be effectively combined for optimal outcomes in biomedical applications.

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  • The utilization of EVs as therapeutic delivery vehicles within the CNS has mainly concentrated on two strategies: native EVs with inherent therapeutic factors and custom-engineered EVs to encapsulate specific therapeutic agents.

    “The utilization of EVs as therapeutic delivery vehicles within the CNS has mainly concentrated on two distinct strategies: first, leveraging native EVs that inherently possess therapeutic factors, and second, custom-engineering EVs to encapsulate and transport specific therapeutic agents.”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [206]

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200 of 496 shown

Authors
Yang, L., Patel, K. D., Rathnam, C., Thangam, R., Hou, Y., Kang, H., & Lee, K.
Affiliations
  • Rutgers, The State University of New Jersey (US)
  • Korea University (KR)
Corresponding author
  • Kang, Heemin
  • Lee, Ki‐Bum
ORCID
Venue
Small
Publisher
Wiley
Published
2022-02-08
Volume
18
Issue
13
Pages
e2104783-e2104783
ISSN
  • 1613-6810 (ISSN-L)
  • 1613-6829
DOI
10.1002/smll.202104783
PMC
PMC9344859
OpenAlex
W4210934146
Cited by
81
References
507
Citations by year
2026: 6 · 2025: 21 · 2024: 26 · 2023: 21 · 2022: 7
FWCI
1.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Small (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ANU Open Research (Australian National University) (submittedVersion)
Funders
  • National Science Foundation (CBET‐1803517)
  • New Jersey Commission on Spinal Cord Research (CSCR17IRG010, CSCR16ERG019)
  • National Institutes of Health (R21AR071101, 1R01DC016612, 3R01DC016612‐01S1, 5R01DC016612‐02S1, 3R01DC016612‐04S2, 3R01DC016612‐04S1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
extracellular vesicles, exosomes, magnetic nanomaterials, extracellular vesicle isolation, drug delivery, tissue engineering, regenerative medicine, theranostics, disease diagnosis, biomolecule delivery
MeSH terms
Extracellular Vesicles, Theranostic Nanomedicine, Nanostructures, Exosomes, Magnetic Phenomena

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