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Cited by 16Pregnancy and preeclampsia studiesNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

Placental Drug Delivery to Treat Pre‐Eclampsia and Fetal Growth Restriction

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Deepak, Venkataraman, El‐Balawi, Lujain, Harris, Lynda K·2024·Small
DOI 10.1002/smll.202311165
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Abstract

Pre‐eclampsia and fetal growth restriction (FGR) continue to cause unacceptably high levels of morbidity and mortality, despite significant pharmaceutical and technological advances in other disease areas. The recent pandemic has also impacted obstetric care, as COVID‐19 infection increases the risk of poor pregnancy outcomes. This review explores the reasons why it lacks effective drug treatments for the placental dysfunction that underlies many common obstetric conditions and describes how nanomedicines and targeted drug delivery approaches may provide the solution to the current drug drought. The ever‐increasing range of biocompatible nanoparticle formulations available is now making it possible to selectively deliver drugs to uterine and placental tissues and dramatically limit fetal drug transfer. Formulations that are refractory to placental uptake offer the possibility of retaining drugs within the maternal circulation, allowing pregnant individuals to take medicines previously considered too harmful to the developing baby. Liposomes, ionizable lipid nanoparticles, polymeric nanoparticles, and adenoviral vectors have all been used to create efficacious drug delivery systems for use in pregnancy, although each approach offers distinct advantages and limitations. It is imperative that recent advances continue to be built upon and that there is an overdue investment of intellectual and financial capital in this field.

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  • Identifying FGR risk at 20-24 weeks - before overt restriction - creates opportunities for proactive management.

    “Identifying FGR risk at 20–24 weeks – before overt restriction – creates opportunities for proactive management.2,13,31,32”

    From Early detection of severe fetal growth restriction using multimodal deep learning based on ultrasound and prenatal biomarkers (2026) · cites this paper as [2]

    Section 4, “Expanding the Treatment Options for Pre-Eclampsia and FGR” (page unavailable), says therapeutic interventions aim to manage associated pathologies and safely extend gestation. It does not describe identifying FGR risk at 20–24 weeks before overt restriction or establish that doing so enables proactive management. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

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Authors
Deepak, V., El‐Balawi, L., & Harris, L. K.
Affiliations
  • Manchester Academic Health Science Centre (GB)
  • University of Manchester (GB)
Corresponding author
Harris, Lynda K
ORCID
Venue
Small
Publisher
Wiley
Published
2024-05-15
Volume
20
Issue
41
Pages
e2311165-e2311165
ISSN
  • 1613-6810 (ISSN-L)
  • 1613-6829
DOI
10.1002/smll.202311165
OpenAlex
W4396932852
Cited by
16
References
174
Citations by year
2026: 5 · 2025: 9 · 2024: 2
FWCI
1.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Small (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion, other-oa)
Funders
  • Bill and Melinda Gates Foundation (INV‐032265)
  • Manchester Biomedical Research Centre
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
preeclampsia, fetal growth restriction, placental insufficiency, nanomedicine, targeted drug delivery, nanoparticle formulation, liposomes, ionizable lipid nanoparticles, polymeric nanoparticles, adenoviral vector, maternal-fetal drug transfer, drug safety in pregnancy
MeSH terms
COVID-19, Female, Fetal Growth Retardation, Humans, Liposomes, Placenta, Pre-Eclampsia, Pregnancy, Drug Delivery Systems, Nanoparticles

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