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Regulation of Peptide Liquid–Liquid Phase Separation by Aromatic Amino Acid Composition
Open accessAbstract
Membraneless organelles are cellular biomolecular condensates that are formed by liquid–liquid phase separation (LLPS) of proteins and nucleic acids. LLPS is driven by multiple weak attractive forces, including intermolecular interactions mediated by aromatic amino acids. Considering the contribution of π‐electron bearing side chains to protein‐RNA LLPS, systematically study sought to how the composition of aromatic amino acids affects the formation of heterotypic condensates and their physical properties. For this, a library of minimalistic peptide building blocks is designed containing varying number and compositions of aromatic amino acids. It is shown that the number of aromatics in the peptide sequence affect LLPS propensity, material properties and (bio)chemical stability of peptide/RNA heterotypic condensates. The findings shed light on the contribution of aromatics’ composition to the formation of heterotypic condensates. These insights can be applied for regulation of condensate material properties and improvement of their (bio)chemical stability, for various biomedical and biotechnological applications.
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Cites
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
Martin, E. W., Holehouse, A. S., Peran, I., Farag, M., Incicco, J. J., Bremer, A., Grace, C. R., Soranno, A., Pappu, R. V., & Mittag, T. (2020) · Science · doi:10.1126/science.aaw8653 · Cited by 1,147
Aumiller, W. M., Pir Cakmak, F., Davis, B. W., & Keating, C. D. (2016) · Langmuir · doi:10.1021/acs.langmuir.6b02499 · Cited by 325
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Metadata
- Authors
- Netzer, A., Baruch Leshem, A., Veretnik, S., Edelstein, I., & Lampel, A.
- Affiliations
- Tel Aviv University (IL)
- Shmunis School of Biomedicine and Cancer Research George S. Wise Faculty of Life Sciences Tel Aviv University Tel Aviv 69978 Israel
- Corresponding author
- Lampel, Ayala
- Venue
- Small
- Publisher
- Wiley
- Published
- 2024-05-28
- Volume
- 20
- Issue
- 38
- Pages
- e2401665-e2401665
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W4399077457
- Cited by
- 28
- References
- 2
- Citations by year
- 2026: 12 · 2025: 16
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Small (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation (2589/21)
- Colton Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- liquid-liquid phase separation, aromatic amino acids, biomolecular condensates, π-electron interaction, condensate stability
- MeSH terms
- Phase Separation, Peptides, RNA, Amino Acids, Aromatic
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