The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Lubricating and dual-responsive injectable hydrogels formulated from ZIF-8 facilitate osteoarthritis treatment by remodeling the microenvironment
Abstract
Osteoarthritis (OA) is a progressively developing condition primarily characterized by the deterioration of articular cartilage and the proliferation of bone, along with ongoing inflammation. Although the precise pathogenesis remains somewhat elusive, restoring the homeostatic balance of the intra-articular microenvironment is crucial for the management of OA. Intra-articular injection of medication is one of the most direct and effective treatment methods; however, most injectable drugs used for osteoarthritis treatment, due to their rapid breakdown, quick release, poor biological activity, and frequent injections, leading to increased risk of infection and suboptimal therapeutic outcomes. In this study, a lubricating and dual-responsive injectable hydrogel based on zeolitic imidazolate frameworks-8 (ZIF-8) impregnated with Quercetin (Que) is designed, which can facilitate OA treatment by remodeling the microenvironment. The prepared injectable nanocomposite hydrogel (MH/CCM@ZIF-8@Que) exhibits pH and reactive oxygen species (ROS) responsiveness, alongside a controllable release of bioactive substances to modulate the microenvironment of bone tissue, thereby mitigating synovitis and the degeneration of cartilage matrix, while simultaneously facilitating cartilage repair. This developed thermosensitive injectable hydrogel, which effectively balances lubrication with the controlled release of bioactive substances, represents a highly promising therapeutic approach for osteoarthritis.
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“Concurrently, Zn2+ promotes macrophage polarization towards the anti-inflammatory M2 phenotype, inhibits pro-inflammatory cytokines such as TNF-α and IL-1β, and upregulates reparative factors including IL-10 and Arg-1 [44].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [44]
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Cites
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Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review
Katz, J. N., Arant, K. R., & Loeser, R. F. (2021) · JAMA · doi:10.1001/jama.2020.22171 · Cited by 2,305
Metal–Organic Framework‐Based Stimuli‐Responsive Systems for Drug Delivery
Cai, W., Wang, J., Chu, C., Chen, W., Wu, C., & Liu, G. (2019) · Advanced Science · doi:10.1002/advs.201801526 · Cited by 744
Colloidal metal–organic framework particles: the pioneering case of ZIF-8
Troyano, J., Carné-Sánchez, A., Avci, C., Imaz, I., & Maspoch, D. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00472f · Cited by 461
Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis
Hodgkinson, T., Kelly, D. C., Curtin, C. M., & O’Brien, F. J. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00724-w · Cited by 397
Recent advances on the improvement of quercetin bioavailability
Kandemir, K., Tomas, M., McClements, D. J., & Capanoglu, E. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.11.032 · Cited by 333
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Chen, M., Lu, Y., Liu, Y., Liu, Q., Deng, S., Liu, Y., Cui, X., Liang, J., Zhang, X., Fan, Y., et al. (2024) · Advanced Materials · doi:10.1002/adma.202312559 · Cited by 182
Self-citationHuang, L., Zhu, Z., Wu, D., Gan, W., Zhu, S., Li, W., Tian, J., Li, L., Zhou, C., & Lu, L. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115110 · Cited by 172
Cited by
Si, Y., Li, X., Dong, S., Gao, X., Zhu, Y., Mo, L., Wang, Z., Wang, S., & Zhang, C. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.026 · Cited by 17
“Concurrently, Zn 2 + promotes macrophage polarization towards the anti-inflammatory M2 phenotype, inhibits pro-inflammatory cytokines such as TNF-α and IL-1 β , and upregulates reparative factors including IL-10 and Arg-1 [44].”
Metadata
- Authors
- Zhang, H., Yuan, S., Zheng, B., Wu, P., He, X., Zhao, Y., Zhong, Z., Zhang, X., Guan, J., Wang, H., Yang, L., & Zheng, X.
- Affiliations
- Zhongshan People's Hospital (CN)
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- Tongji University (CN)
- Third Hospital of Hebei Medical University (CN)
- University of Macau (MO)
- Department of Pharmacy the First Affiliated Hospital State Key Laboratory of Frigid Zone Cardiovascular Diseases Science and Technology Planning Project of Guangzhou Jinan University Guangzhou 510630 P. R. China
- Harbin Medical University (CN)
- Corresponding author
- Guan, Jian
- Wang, Huajun
- Yang, Lei
- Zheng, Xiaofei
- ORCID
- Venue
- Small
- Publisher
- Wiley
- Published
- 2024-11-27
- Volume
- 21
- Issue
- 3
- Pages
- e2407885-e2407885
- ISSN
- 1613-6810 (ISSN-L)
- 1613-6829
- OpenAlex
- W4404830215
- Cited by
- 45
- References
- 48
- Citations by year
- 2026: 27 · 2025: 18
- FWCI
- 14.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- onlinelibrary.wiley.com/termsAndConditions#vor (vor)
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
- Locations
- Small (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2022YFE0206200, 2023YFC2414500)
- National Natural Science Foundation of China (82172440, 82360941)
- Natural Science Foundation of Guangdong Province (2023A0505020008, 2023A1515011860, 2023A1515140034, 2023A1515140076)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- osteoarthritis, injectable hydrogel, ZIF-8, zeolitic imidazolate frameworks, quercetin, pH-responsive drug release, reactive oxygen species-responsive release, thermosensitive hydrogel, cartilage repair, synovitis, intra-articular injection, lubrication, dual-responsive drug delivery, articular cartilage degeneration
- MeSH terms
- Metal-Organic Frameworks, Animals, Cartilage, Articular, Humans, Imidazoles, Injections, Lubrication, Osteoarthritis, Quercetin, Reactive Oxygen Species, Zeolites, Hydrogels, Nanocomposites, Lubricants, Cellular Microenvironment
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