Figo stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: An analysis of 1973‐87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina
Abstract
The prognostic impact of FIGO stage, histology, histologic grade, age and race in survival for cancers of the female gynecological (cervix, endometrium, ovary, vulva, vagina) were examined using cases obtained from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program that were diagnosed between 1973 and 1987. Utilizing Cox proportional hazards modeling and relative survival rates analysis of 17,119 cases of cervical cancer indicated that the International Federation of Gynecology and Obstetrics (FIGO) stage, histology, histological grade, lymph node status, and age at diagnosis were all independently prognostic. No evidence was found of survival differences between squamous cell carcinoma and adenocarcinoma. Younger women were not found to have a poorer prognosis, survival declined with increased age. Analysis of 41,120 cases of endometrial cancer indicated that FIGO stage, histology, histologic grade, lymph node status, age at diagnostic, and race were all prognostic factors. Clear cell adenocarcinoma, leiomyosarcoma, and mixed mullerian tumors were all found to have poorer prognosis. Analysis of 21,240 cases of ovarian cancer indicated that FIGO stage, histology, histologic grade, lymph node status, age at diagnosis, presence of ascites, and race were all prognostically significant. Analysis of 2,575 cases of vulvar cancer indicated that FIGO stage, histology, histologic grade, age, and race were all prognostically significant. Analysis…
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Prognosis of cervical carcinoma is related to clinical stage, lymph node metastasis, parametrial invasion, primary tumor size, histological type, depth of cervical stromal invasion and lymph vascular space involvement.
“Prognosis of cervical carcinoma is related to clinical stage, lymph node metastasis, parametrial invasion, primary tumor size, histological type, depth of cervical stromal invasion and lymph vascular space involvement [37].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [37]
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Senapati, R., Nayak, B., Kar, S. K., & Dwibedi, B. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-016-2136-4 · Cited by 95 · see citing works
“Prognosis of cervical carcinoma is related to clinical stage, lymph node metastasis, parametrial invasion, primary tumor size, histological type, depth of cervical stromal invasion and lymph vascular space involvement [37].”
BackgroundLi, Q., Sun, Y., Zhang, X., Wang, L., Wu, W., Wu, M., Meng, C., & Liu, G. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1595278 · Cited by 30 · see citing works
- Authors
- Kosary, C. L.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Kosary, Carol L.
- Venue
- Seminars in Surgical Oncology
- Publisher
- Wiley
- Published
- 1994-01
- Volume
- 10
- Issue
- 1
- Pages
- 31-46
- ISSN
- 1098-2388 (ISSN-L)
- 8756-0437
- OpenAlex
- W1992743577
- Cited by
- 417
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 16 · 2019: 5 · 2018: 16 · 2017: 18 · 2016: 19 · 2015: 13 · 2014: 13 · 2013: 24 · 2012: 21
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Surgical Oncology (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- FIGO stage, histologic grade, histology, age at diagnosis, race, prognostic factors, survival, cervical cancer, endometrial cancer, ovarian cancer, vulvar cancer, vaginal cancer, lymph node status, clear cell adenocarcinoma, leiomyosarcoma, mixed Mullerian tumor, ascites, SEER
- MeSH terms
- Adenocarcinoma, Adult, Age Factors, Aged, Analysis of Variance, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Female, Forecasting, Genital Neoplasms, Female, Humans, Lymphatic Metastasis, Middle Aged, National Institutes of Health (U.S.), Neoplasm Staging, Ovarian Neoplasms, Population Surveillance, Prognosis, Registries, United States, Vaginal Neoplasms, Vulvar Neoplasms, Survival Rate, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Databases, Factual, Endometrial Neoplasms, Age of Onset
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