Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells

de Witte, Samantha F.H.; Luk, Franka; Sierra Parraga, Jesus M.; Gargesha, Madhu; Merino, Ana; Korevaar, Sander S.; Shankar, Anusha S.; O'Flynn, Lisa; Elliman, Steve J.; Roy, Debashish; Betjes, Michiel G.H.; Newsome, Philip N.; Baan, Carla C.; Hoogduijn, Martin J.

doi:10.1002/stem.2779

Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells

Mesenchymal stem or stromal cells (MSC) are under investigation as a potential immunotherapy. MSC are usually administered via intravenous infusion, after which they are trapped in the lungs and die and disappear within a day. The fate of MSC after their disappearance from the lungs is unknown an…