CoChat
Sign Up
Cited by 3Origins and Evolution of LifeAdvanced Thermodynamics and Statistical MechanicsComplex Systems and Dynamics

Steady Out‐of‐Equilibrium Chemistry: What? Why? How?

Open access
Plasson, Raphaël, Jullien, Ludovic·2025·ChemSystemsChem
DOI 10.1002/syst.202500011
Open this paper in CoChat — free accountOpen PDF

Abstract

There is an active interest in living matter from a systemic perspective. Whereas the targeted goal of producing living matter remains elusive, it may currently be useful to recognize some steps along the way and underline their intrinsic value, independently of the final goal. Hence, conceived to support further research in the field, this account evokes several preliminary developments which have only been partially performed, methodologies that could be engaged, and difficulties that are worth considering for optimal design of the future experimental plans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/syst.202500011

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 116

  1. B. Bhushan, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 2009, 367, 1445.
  2. R. F. Ludlow, S. Otto, Chemical Society Reviews 2008, 37, 101.
  3. G. von Kiedrowski, S. Otto, P. Herdewijn, Journal of Systems Chemistry 2010, 1, 1.
  4. K. Ruiz-Mirazo, C. Briones, A. de la Escosura, Chem- ical Reviews 2014, 114, 285.
  5. D. H. Evans, Osmotic and Ionic Regulation: Cells and Animals, CRC Press Inc, Boca Raton 2008.
  6. K. R. Albe, M. H. Butler, B. E. Wright, Journal of Theoretical Biology 1990, 143, 163.
  7. B. D. Bennett, E. H. Kimball, M. Gao, R. Osterhout, S. J. V. Dien, J. D. Rabinowitz, Nature Chemical Biology 2009, 5, 593.
  8. K. Nicolaou, Angew. Chem. Int. Ed 2013, 52, 131.
  9. L. Jullien, A. Proust, J.-C. Le Menn, Journal of chem- ical education 1998, 75, 194.
  10. L. Michaelis, M. L. Menten, et al., Biochem. z 1913, 49, 352.
  11. R. A. Marcus, Angewandte Chemie International Edi- tion in English 1993, 32, 1111.
  12. T. L. Hill, Free Energy Transduction in Biology, the Steady-State Kinetic and Thermodynamic Formalism, Academic Press, New York 1977.
  13. D. A. Beard, H. Qian, Chemical Biophysics: Quanti- tative Analysis of Cellular Systems, volume 126, Cam- bridge University Press Cambridge 2008.
  14. G. S. Hammond, Journal of the American Chemical Society 1955, 77, 334.
  15. H. Makita, G. Hastings, Proceedings of the National Academy of Sciences 2017, 114, 9267.
  16. R. B. Martin, Biopolymers: Original Research on Biomolecules 1998, 45, 351.
  17. E. L. Shock, Geochimica et Cosmochimica Acta 1992, 56, 3481.
  18. N. Kitadai, Journal of molecular evolution 2014, 78, 171.
  19. A. Radzicka, R. Wolfenden, Journal of the American Chemical Society 1996, 118, 6105.
  20. H. Flodgaard, P. Fleron, Journal of Biological Chem- istry 1974, 249, 3465.
  21. L. de Meis, Journal of Biological Chemistry 1984, 259, 6090.
  22. R. N. Goldberg, Y. B. Tewari, The Journal of Chemical Thermodynamics 2002, 34, 821.
  23. D. O. Campbell, M. L. Kilpatrick, Journal of the American Chemical Society 1954, 76, 893.
  24. M. Kawabe, O. Ohashi, I. Yamaguchi, Bulletin of the Chemical Society of Japan 1970, 43, 3705.
  25. R. B. Stockbridge, R. Wolfenden, Journal of Biological Chemistry 2011, 286, 18538.
  26. S. D'Amico, T. Collins, J.-C. Marx, G. Feller, C. Ger- day, C. Gerday, EMBO reports 2006, 7, 385.
  27. F. Sagués, I. R. Epstein, Dalton transactions 2003, pages 1201-1217.
  28. M. J. Klein, Physical Review 1955, 97, 1446.
  29. A. Pross, V. Khodorkovsky, Journal of Physical Or- ganic Chemistry 2004, 17, 312.
  30. A. Pross, R. Pascal, Life 2023, 13, 2171.
  31. G. Nicolis, I. Prigogine, Self-Organization in Nonequi- librium Systems: From Dissipative Structures to Order through Fluctuations, Wiley 1977.
  32. I. R. Epstein, J. A. Pojman, An Introduction to Nonlin- ear Chemical Dynamics: Oscillations, Waves, Patterns, and Chaos, Oxford university press 1998.
  33. N. Lane, J. F. Allen, W. Martin, BioEssays : news and reviews in molecular, cellular and developmental biology 2010, 32, 271.
  34. E. Braun, Reports on Progress in Physics 2015, 78, 036602.
  35. K. Jaouadi, M. Abdellaoui, E. Levernier, P.-a. Payard, E. Derat, T. Le Saux, C. Ollivier, S. Torelli, L. Jullien, R. Plasson, et al., Chemistry-A European Journal 2023, 29, e202301780.
  36. J. N. Israelachvili, Intermolecular and surface forces, Academic press 2011.
  37. S. J. Wodak, E. Paci, N. V. Dokholyan, I. N. Bere- zovsky, A. Horovitz, J. Li, V. J. Hilser, I. Bahar, J. Karanicolas, G. Stock, et al., Structure 2019, 27, 566.
  38. B. J. Shields, J. Stevens, J. Li, M. Parasram, F. Damani, J. I. M. Alvarado, J. M. Janey, R. P. Adams, A. G. Doyle, Nature 2021, 590, 89.
  39. J. J. Hopfield, Proceedings of the National Academy of Sciences 1974, 71, 4135.
  40. J. Ninio, Biochimie 1975, 57, 587.
  41. S. Ghosh, M. G. Baltussen, N. M. Ivanov, R. Haije, M. Jakštaitė, T. Zhou, W. T. S. Huck, Chemical Re- views 2024, 124, 2553.
  42. M. Emond, T. L. Saux, J.-F. Allemand, P. Pelupessy, R. Plasson, L. Jullien, Chemistry A European Journal 2012, 18, 14375.
  43. F. Jülicher, A. Ajdari, J. Prost, Reviews of Modern Physics 1997, 69, 1269.
  44. L. Jullien, A. Lemarchand, The Journal of Physical Chemistry B 2001, 105, 4415.
  45. L. Jullien, A. Lemarchand, S. Charier, O. Ruel, J.-B. Baudin, The Journal of Physical Chemistry B 2003, 107, 9905.
  46. A. Lemarchand, L. Jullien, Physical Chemistry Chem- ical Physics 2004, 6, 398.
  47. G. Ragazzon, L. J. Prins, Nature nanotechnology 2018, 13, 882.
  48. R. D. Astumian, Annual review of biophysics 2011, 40, 289.
  49. B. A. Grzybowski, W. T. Huck, Nature nanotechnology 2016, 11, 585.
  50. S. Borsley, D. A. Leigh, B. M. Roberts, Angewandte Chemie International Edition 2024, 63, e202400495.
  51. J.-P. Sauvage, Angewandte Chemie International Edi- tion 2017, 56, 11080.
  52. J. F. Stoddart, Angew. Chem. Int. Ed 2017, 56, 11094.
  53. B. L. Feringa, Angewandte Chemie-International Edi- tion 2017, 56, 11059.
  54. B. Liu, J. Wu, M. Geerts, O. Markovitch, C. G. Pappas, K. Liu, S. Otto, Angewandte Chemie International Edition 2022, 61, e202117605.
  55. A. Sood, P. K. Mandal, J. Ottelé, J. Wu, M. Eleveld, J. Hatai, C. G. Pappas, I. Huc, S. Otto, Journal of the American Chemical Society 2024, 146, 33386.
  56. T. L. Saux, R. Plasson, L. Jullien, Chemical Commu- nications 2014, 50, 6189.
  57. I. Cvrtila, S. Otto, Chemistry -A European Journal 2024, page e202403157.
  58. M. Loukili, L. Jullien, G. Baffou, R. Plasson, Physical Review E 2025, 111, 034209.
  59. C. Amatore, F. Bonhomme, J.-L. Bruneel, L. Servant, L. Thouin, J. Elec. Chem. 2000, 484, 1.
  60. H. Wu, B. Huang, R. N. Zare, Journal of The American Chemical Society 2006, 128, 4194.
  61. S. K. W. Dertinger, D. T. Chiu, N. L. Jeon, G. M. Whitesides, Analytical Chemistry 2001, 73, 1240.
  62. J. Olofsson, H. Bridle, J. Sinclair, D. Granfeldt, E. Sahlin, O. Orwar, Proceedings of the National Academy of Sciences of the United States of Amer- ica 2005, 102, 8097.
  63. C. M. Dobson, G. B. Ellison, A. F. Tuck, V. Vaida, Proceedings of the National Academy of Sciences 2000, 97, 11864.
  64. A. Fallah-Araghi, K. Meguellati, J.-C. Baret, A. E. Har- rak, T. Mangeat, M. Karplus, S. Ladame, C. M. Mar- ques, A. D. Griffiths, Physical Review Letters 2014, 112, 028301.
  65. A. B. Grommet, M. Feller, R. Klajn, Nature nanotech- nology 2020, 15, 256.
  66. L. E. Orgel, Origins of Life and Evolution of the Bio- sphere 1998, 28, 227.
  67. J.-F. Lambert, Origins of Life and Evolution of Bio- spheres 2008, 38, 211.
  68. A. Würger, Reports on Progress in Physics 2010, 73, 126601.
  69. C. B. Mast, S. Schink, U. Gerland, D. Braun, Proceed- ings of the National Academy of Sciences of the United States of America 2013, 110, 8030.
  70. A. Lemarchand, L. Jullien, The Journal of Physical Chemistry B 2004, 108, 11782.
  71. S. Liang, D. M. Busiello, P. De Los Rios, New Journal of Physics 2022, 24, 123006.
  72. D. M. Busiello, S. Liang, F. Piazza, P. De Los Rios, Communications Chemistry 2021, 4, 16.
  73. O. K. Tawfik, D. S, Annual review of biochemistry 2010, 79, 471.
  74. D. Andrieux, P. Gaspard, Proceedings of the National Academy of Sciences 2008, 105, 9516.
  75. H. Qian, D. A. Beard, IEE Proceedings-Systems Biol- ogy 2006, 153, 192.
  76. G. Steinberg-Yfrach, P. A. Liddell, S.-C. Hung, A. L. Moore, D. Gust, T. A. Moore, Nature 1997, 385, 239.
  77. X. Xie, G. A. Crespo, G. Mistlberger, E. Bakker, Na- ture chemistry 2014, 6, 202.
  78. B. Shao, H. Fu, I. Aprahamian, Science 2024, 385, 544.
  79. K. Liang, F. Nicoli, S. A. Shehimy, E. Penocchio, S. Di Noja, Y. Li, C. Bonfio, S. Borsley, G. Ragazzon, Angewandte Chemie International Edition 2025, page e202421234.
  80. A. Katchalsky, P. F. Curran, Nonequilibrium Ther- modynamics in Biophysics, Harvard University Press, Cambridge 1965.
  81. S. Lems, H. J. van der Kooi, J. de Swaan Arons, Chemical Engineering Science 2003, 58, 2001.
  82. R. Plasson, A. Brandenburg, Origins of Life and Evo- lution of Biospheres 2010, 40, 93.
  83. D. Soloveichik, G. Seelig, E. Winfree, Proceedings of the National Academy of Sciences of the United States of America 2010, 107, 5393.
  84. R. Pascal, A. Pross, J. D. Sutherland, Open Biology 2013, 3, 130156.
  85. S. J. Admiraal, D. Herschlag, Chemistry & Biology 1995, 2, 729.
  86. M. Eigen, Angewandte Chemie International Edition 1964, 3, 1.
  87. P. Mitchell, European Journal of Biochemistry 1979, 95, 1.
  88. A. Goldbeter, D. E. Koshland Jr, Proceedings of the National Academy of Sciences 1981, 78, 6840.
  89. K. Montagne, R. Plasson, Y. Sakai, T. Fujii, Y. Ron- delez, Mol Syst Biol 2011, 7, 466.
  90. R. Plasson, H. Bersini, The Journal of Physical Chem- istry B 2009, 113, 3477.
  91. R. Plasson, Y. Rondelez, Synthetic Biochemical Dy- namic Circuits, in M. Pesenson (Editor), Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain, Wiley-VCH Verlag GmbH & Co. KGaA 2013 pages 113-145.
  92. R. Plasson, A. Brandenburg, L. Jullien, H. Bersini, Journal of Physical Chemistry A 2011, 115, 8073.
  93. G. von Kiedrowski, Angewandte Chemie International Edition in English 1986, 25, 932.
  94. D. Braun, N. L. Goddard, A. Libchaber, Physical Review Letters 2003, 91, 158103.
  95. M. Eigen, P. Schuster, The Hypercycle, a Principle of Natural Self-Organization, Springer, Berlin 1979.
  96. J. C. Xavier, W. Hordijk, S. Kauffman, M. Steel, W. F. Martin, Proceedings of the Royal Society B 2020, 287, 20192377.
  97. J. D. Farmer, S. A. Kauffman, N. H. Packard, Physica D: Nonlinear Phenomena 1986, 22, 50.
  98. A. Blokhuis, D. Lacoste, P. Nghe, Proceedings of the National Academy of Sciences 2020, 117, 25230.
  99. S. Yao, I. Ghosh, R. Zutshi, J. Chmielewski, Nature 1998, 396, 447.
  100. G. Ashkenasy, R. Jagasia, M. Yadav, M. R. Ghadiri, Proceedings of the National Academy of Sciences 2004, 101, 10872.
  101. F. Schaufelberger, O. Ramstrom, Journal of the Amer- ican Chemical Society 2016, 138, 7836.
  102. H. Morowitz, E. Smith, Complexity 2007, 13, 51.
  103. R. Pascal, L. Boiteau, Phil. Trans. Roy. Soc. B: Biol. Sci. 2011, 366, 2949.
  104. T. Hill, Free Energy Transduction in Biology: The Steady-State Kinetic and Thermodynamic Formalism, Elsevier 2012.
  105. R. Braakman, E. Smith, Physical Biology 2013, 10, 011001.
  106. T. Le Saux, R. Plasson, L. Jullien, Chemical Commu- nications 2014, 50, 6189.
  107. C. H. Bennett, International Journal of Theoretical Physics 1982, 21, 905.
  108. M. O. Magnasco, Phys. Rev. Lett. 1997, 78, 1190.
  109. M. Cook, D. Soloveichik, E. Winfree, J. Bruck, Pro- grammability of Chemical Reaction Networks, in A. Condon, D. Harel, J. N. Kok, A. Salomaa, E. Win- free (Editors), Algorithmic Bioprocesses, Natural Com- puting Series, pages 543-584, Springer, Berlin, Heidel- berg 2009.
  110. C. E. Cleland, C. F. Chyba, Origins of Life and Evo- lution of the Biosphere 2002, 32, 387.
  111. S. A. Benner, Astrobiology 2010, 10, 1021.
  112. E. Arunachalam, W. Ireland, X. Yang, D. Needleman, Annual Review of Condensed Matter Physics 2023, 14, 211.
  113. J. J. Agresti, E. Antipov, A. R. Abate, K. Ahn, A. C. Rowat, J.-C. Baret, M. Marquez, A. M. Klibanov, A. D. Griffiths, D. A. Weitz, Proceedings of the National Academy of Sciences 2010, 107, 4004.
  114. M. D. Lane, B. Seelig, Current opinion in chemical biology 2014, 22, 129.
  115. A. Currin, N. Swainston, P. J. Day, D. B. Kell, Chem- ical Society Reviews 2015, 44, 1172.
  116. M. S. Packer, D. R. Liu, Nature Reviews Genetics 2015, 16, 379.

Cited by

Sorted by citations

Authors
Plasson, R., & Jullien, L.
Affiliations
  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
  • Plasson, Raphaël
  • Jullien, Ludovic
ORCID
Venue
ChemSystemsChem
Publisher
Wiley
Published
2025-05-30
Volume
7
Issue
5
ISSN
2570-4206 (ISSN-L)
DOI
10.1002/syst.202500011
OpenAlex
W4410885154
Cited by
3
References
3
Citations by year
2026: 3
FWCI
1.33
Type
journal article
Language
en
Open access
Licence
Locations
  • ChemSystemsChem (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
Agence Nationale de la Recherche (ANR‐19‐CE6‐0010‐02)
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Advanced Thermodynamics and Statistical Mechanics
  • Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Systems and Dynamics
Keywords
living matter, synthetic biology, non-equilibrium thermodynamics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review