The host response to allogeneic and xenogeneic biological scaffold materials: Host response to biological scaffoldsc
Open accessAbstract
The clinical use of biological scaffold materials has become commonplace. Such scaffolds are composed of extracellular matrix (ECM), or components of ECM, derived from allogeneic or xenogeneic tissues. Such scaffold materials vary widely in their source tissue, processing methods and sterilization methods. The success or failure of an ECM scaffold for a given application is dependent on the host response following implantation; a response that is largely mediated by the innate immune system and which is influenced by a numerous factors, including the processing methods used in the preparation of biological scaffolds. The present paper reviews various aspects of the host response to biological scaffolds and factors that affect this response. In addition, some of the logistical, regulatory and reconstructive implications associated with the use of biological scaffolds are discussed.
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During degradation of implanted ECM bioscaffolds, ECM components are released and promote the transition to a remodeling phase.
“What is more, it is widely accepted that during the degradation of implanted ECM bioscaffolds, ECM components are released into the environment and promote the transition to a remodeling phase [18,44,74,78].”
From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [78]
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References 78 · Cited by 139
- Authors
- Keane, T. J., & Badylak, S. F.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Badylak, Stephen F.
- Venue
- Journal of Tissue Engineering and Regenerative Medicine
- Publisher
- Hindawi Limited
- Published
- 2014-02-18
- Volume
- 9
- Issue
- 5
- Pages
- 504-511
- ISSN
- 1932-6254 (ISSN-L)
- OpenAlex
- W1901274024
- Cited by
- 139
- References
- 78
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 17 · 2020: 13 · 2019: 15 · 2018: 10 · 2017: 13 · 2016: 11 · 2015: 9 · 2014: 5
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Tissue Engineering and Regenerative Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- biological scaffolds, host response, extracellular matrix, innate immune response, sterilization, tissue reconstruction
- MeSH terms
- Animals, Epitopes, Biocompatible Materials, Extracellular Matrix, Humans, Immune System, Immunity, Innate, Skin, Transplantation, Homologous, Tissue Engineering, Tissue Scaffolds, Adaptive Immunity
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